GROWTH FOLLOWING REPLACEMENT OF THE MANDIBULAR CONDYLE

这项研究将调查长期增长的因素， 颅面骨骼系统的适应性 生长期恒河猴下颌髁状突。 上颌骨的生长， 下颌骨双侧髁状突置换术后使用自体1） 下颌骨髁，2）骨，3）锁骨胸骨髁，和4） 肋骨肋软骨连接处将使用24 幼年雌性猕猴作为实验对象。 改编 在颞下颌关节内将进行组织学评价， 移植后几年。 根据我们实验室以前的研究，以下具体 假设，或预测，提出了：1）双边替代 下颌骨髁与自体下颌骨髁将导致 下颌骨的正常生长; 2）双侧下颌骨置换 植入骨移植物的髁将导致异常生长， 下颌骨生长不足; 3）双侧下颌骨置换 髁与肋骨的肋软骨连接处将导致 下颌骨生长不协调; 4）双侧替换 下颌骨髁突与锁骨胸骨端的接触将导致 下颌骨的持续和谐生长 这项研究的结果将直接和立即影响到 颅面复合体生长的相关临床问题， 下颌骨髁状突发育不全。 结果将有助于 外科医生在选择一个移植，为病人提供一个更好的机会， 和谐的面部生长，当临床上用于取代有缺陷的 下颌髁

This research will investigate the factors involved in long-term growth and adaptation of the craniofacial skeletal system following replacement of the mandibular condyle in growing Macaca mulatta. Growth of the maxilla and mandible after bilateral condylar replacement using autogenous 1) mandibular condyles, 2) bone, 3) sternal condyle of the clavicles, and 4) costochondral junction of ribs will be evaluated cephalometrically using 24 juvenile female Macaca mulatta as experimental subjects. Adaptations within the temporomandibular joints will be evaluated histologically two years following transplantation. Based upon previous studies in our laboratory, the following specific hypotheses, or predictions, are put forward: 1) bilateral replacement of the mandibular condyles with autogenous mandibular condyles will result in normal growth of the mandible; 2) bilateral replacement of the mandibular condyle with a bone graft will result in abnormal growth leading to a deficiency of mandibular growth; 3) bilateral replacement of the mandibular condyle with the costochondral junction of a rib will result in uncoordinated growth of the mandible, and; 4) bilateral replacement of the mandibular condyle with the sternal end of the clavicle will result in continued, harmonious growth of the mandible. The results of this study will have a direct and immediate impact on the related clinical problem of growth of the craniofacial complex following lack of growth of the mandibular condyles. The results will assist the surgeon in selecting a transplant which offers the patient a better chance of harmonious facial growth when used clinically to replace a defective mandibular condyle.