HUMAN GASTRIC PHYSIOLOGY IN HEALTH AND DISEASE

这项提案的具体目标集中在四个关键的调查领域 在人类身上。1.胃肠营养素的控制 禁食-喂食-禁食马达序列。2.餐后关系 液体和固体的压力活动和胃排空。3.中环 神经系统对餐后胃功能的控制，特别是 通过对应激诱导的胃动力和胃运动紊乱的研究 餐后分泌物。4.相关的病理生理机制 上胃肠道的功能性疾病。这些特定的 目标被整合到一个逻辑序列中。从……开始 已建立的方法我们将添加某些新的程序和解决 与人的胃功能控制有关的突出问题。 这些实验的核心是食物性质的影响(在 特别是生理状态和营养成分)对胃运动的影响 活动(具体目标1和2)。这些研究是需要调查的 进一步探讨应激对人体肠道的影响及解决办法 通过中枢神经系统研究这些影响(具体目标3)。 最后，我们将通过调查，将前面的项目汇总在一起 胃功能可能的病理生理异常及其临床意义 功能障碍患者的中央控制(特定目标4)。

The Specific Aims of this proposal focus on four key areas of investigation in man. 1. Control by nutrients of the gastrointestinal fasting-fed-fasting motor sequence. 2. Relations among postprandial pressure activity and gastric emptying of liquids and solids. 3. Central nervous system control of postprandial gastric function, specifically through the study of stress-induced perturbations of gastric motility and secretion after meals. 4. Pathophysiological mechanisms involved in functional diseases of the upper gastrointestinal tract. These Specific Aims are integrated into a logical sequence. Starting from a base of established methods we will add certain novel procedures and address outstanding questions related to the control of gastric functions in man. Central to these experiments is the influence of the nature of food (in particular the phsical state and nutrient composition) on gastric motor activity (Specific Aims 1 and 2). These studies are needed to investigate further the effects of stress on the human gut and to address the mediation of these effects through the central nervous system (Specific Aim 3). Finally, we will bring together the preceding projects by investigating possible pathophysiological abnormalities of gastric function and its central control in patients with functional disorders (Specific Aim 4).