MOTILITY AND TRANSIT ACROSS THE ILEO-CECAL SPHINCTER

回-结肠连接部在调节结肠功能中的作用 胃肠道很少受到关注，尽管有很多 表明这个连接区有重要的功能。 因此 大肠正常反应的能力，通过将食糜转化为 形成的粪便，是由管腔的质量和数量的影响， 内容物到达近端结肠 一般的假设是， 远端回肠、回结肠括约肌（ICS）和近端结肠起作用 作为协调的节段一起调节从回肠到结肠的转运; 此外，这些机制的适当运作， 远端肠道的正常功能 回结肠连接部信息相对缺乏的原因 包括该地区无法进入。 在初始供资期间 在这笔拨款中，已经开发出了允许回结肠 在狗和人中进行研究。 方法提出了在这里连同扩展早期的研究 这将解决的机制，控制运动和过境， 本地区 本文所述的实验具有以下具体目的： 1.利用已建立且表征良好的犬模型， 评价回盲部运动和传输的控制。 的作用 将检查神经肽和药理学试剂。 2.完善回盲部运动和转运的方法， 量化和相关的人，并进一步评估控制 人类回盲部功能。 3.确定回结肠动力障碍在确定的 胃肠道疾病综合征。 这里概述的工作应该有更好的直接应用 了解几种常见的胃肠道疾病，包括 吸收不良综合征，非特异性腹泻，肠易激综合征， 以及胃肠道手术后的术后生理学。

The role of the ileo-colonic junction in modulating performance of the gastrointestinal tract has received little attention, though there is much to suggest that this junctional region has important functions. Thus, the capacity of the large bowel to respond normally, by converting chyme to formed stools, is influenced by the quality and quantity of luminal contents arriving in the proximal colon. The general hypothesis is that the distal ileium, ileocolonic sphincter (ICS) and proximal colon act together as a coordinated segment to regulate transit from ileum to colon; moreover, proper functioning of these mechanisms contributes significantly to normal performance of the distal bowel. Reasons for the relative lack of information on the ileocolonic junction include the inaccessability of the region. In the initial funding period of this grant, methods have been developed which allow the ileocolonic junction to be investigated in dog and man. Further methodological approaches are proposed here together with extensions of earlier studies which will address the mechanisms for control of motility and transit in the region. The experiments described here have the following Specific Aims: 1. To utilize an established and well-characterized canine model to evaluate control of ileocecal motility and transit. The roles of neuro-peptides and pharmacologic agents will be examined. 2. To refine methods by which ileocecal motility and transit can be quantified and correlated in man, and to further evaluate the control of ileocecal function in man. 3. To establish the role of disorders of ileocolonic motility in defined syndromes of gastrointestinal disease. The work outlined here should have direct application to the better understanding of several common gastrointestinal diseases; these include malabsorption syndromes, non-specific diarrhea, irritable bowel syndrome, and the postoperative physiology that follows gastrointestinal surgery.