The molecular basis of endothelial mechanotransduction through TRPV4

该项目旨在了解血流动力学如何协调瞬时受体电位香草酸4（TRPV4）的质膜定位和相互作用，TRPV4是一种在内皮中广泛表达的候选机械敏感离子通道，在心血管系统中具有生理和病理作用，与其他机械受体以及这些事件的生理相关性。血流动力学影响心血管健康和形态发生。该项目将突出TRPV4通道在剪切应力的短期和长期适应性反应中的作用，并将在未来的药物发现中具有重要的应用潜力。

This project aims to understand how blood flow dynamics coordinate the plasma membrane localisation and interaction of the transient receptor potential vanilloid 4 (TRPV4), a candidate mechanosensitive ion channel broadly expressed in endothelium with physiological and pathological roles in the cardiovascular system, with other mechanoreceptors and the physiological relevance of these events. Blood flow haemodynamics affect cardiovascular health and morphogenesis. This project will highlight the role of TRPV4 channels in the short- and long-term adaptive responses to shear stress and will also have significant potential for application in future drug discovery.