ACID AEROSOL EXPOSURE: EFFECTS ON RESPIRATORY MORBIDITY

本研究旨在探讨直接接触呼吸道疾病对人体健康的影响， 暴露于环境空气中的酸性物质将使用 两种互补的观察流行病学方法 阶段。 这项研究的初始阶段将涉及一个 纽约州的纵向观察流行病学研究 它将利用纽约全州规划和研究 合作系统（SPARCS）的住院数据， 与我们每天进行的直接酸性气溶胶测量相结合， 建议在五个城市社区， 不同的酸暴露 健康影响评估将 包括这些数据线性回归和时间序列分析， 辨别急性暴露与 环境酸性气溶胶和呼吸道疾病的每日住院人数 疾病 这项研究的第二阶段将寻求辨别慢性 通过详细的前瞻性研究， 流行病学现场研究，比较两个队列的50 第一阶段社区的学龄儿童（当时有记录） 酸气溶胶浓度有显著差异。 这项工作将 包括使用问卷调查，个人活动日志， 室内采样以评估个人酸性气溶胶暴露。 客观的肺功能测量和症状记录将 在为期两天的活动期间， 每个星期至少进行两次运动， 社区，使急性影响，否则可能混淆 基于单次测量的横截面比较 可以在数据分析中单独控制。 而且 气溶胶分散技术（ADT）的新用途 开发将提供更高的灵敏度，在检测 环境酸暴露对肺功能的潜在影响 气溶胶浓度 第二阶段健康影响分析将 包括对个人使用线性回归模型， 对集体观察进行重复测量ANOVA。 第一阶段和第二阶段的分析将共同提供 对急性和/或慢性 呼吸系统健康的影响发生在一般公众， 酸性气溶胶暴露典型的那些经历在 美国东北

This study of the respiratory health effects of direct human exposures to acidic substances in ambient air will employ complementary observational epidemiologic methods in two phases. The initial phase of this research will involve a longitudinal observational epidemiologic study in New York State which will utilize the N.Y. Statewide Planning and Research Cooperative System (SPARCS) hospital admissions data in conjunction with daily direct acid aerosol measurements which we propose to make in five urban communities expected to have varying acid exposures. The health effects assessment will include linear regression and time series analyses of these data to discern statistical associations between acute exposures to ambient acid aerosols and daily hospital admissions for respiratory disease. The second phase of this research will seek to discern chronic respiratory health effects via a detailed prospective epidemiologic field study comparing two cohorts of 50 schoolchildren in Phase I communities with (then documented) significantly different acid aerosol concentrations. This work will include the use of questionnaires, personal activity journals, and indoor sampling to assess individual acid aerosol exposures. Objective lung function measurements and symptom records will be made daily for each participant over a campaign period of two weeks and at least two campaigns will be conducted in each community so that acute effects, which might otherwise confound cross-sectional comparisons based upon single measurements alone, may be controlled for in the data analysis. Moreover, the additional use of the Aerosol Dispersion Technique (ADT) recently developed will provide greater sensitivity in the detection of potential lung function effects of exposures at ambient acid aerosol concentrations. The Phase II health effects analysis will include the use of linear regression models on individuals and repeated measures ANOVA on the collective observations. Together, the Phase I and Phase II analyses will provide a balanced investigation of the potential for acute and/or chronic respiratory health effects to occur in the general public from acidic aerosol exposures typical of those experienced in the Northeastern U.S.