EPIDEMIOLOGY OF FETAL DEATH AND PESTICIDE EXPOSURE

这项建议的目的是改善和扩大现有的 孕期胎儿死亡与农药暴露的研究。 有许多杀虫剂被认为具有 致畸/致突变潜力，以及这些和其他常见的 圣华金河谷正在研究使用过的杀虫剂 加州有大量使用杀虫剂的地方。这个 流行病学研究设计为病例对照，病例为致命性病例 已从胎儿死亡证明中确认的死亡 对照是随机选择的活产(在匹配范围内 不同的阶层)来自相同的县。有644个病例 胎儿死亡和644例对照出生。 具体目标如下：1)增加问卷调查 电话和邮件的应答率(应答率 到目前为止，我们有好地址的主题的评级是 55%)、2)找到我们无法找到的研究对象 因出生证明上的过时地址而联系 胎儿死亡(24%的研究对象)，3)对住宅进行地理编码 怀孕期间与农药使用有关的地址 限制农药的数据，4)开发计算机算法 确定与居住地相邻的路段 农药联动(一个区段是乡镇内的平方英里单位 和范围)、5)关于医疗、环境和其他方面的代码数据 问卷收集的因素，以及6)分析 婴幼儿低出生体重儿与农药暴露的关系 活产儿对照组。

The purpose of this proposal is to improve and expand an existing study of fetal death and pesticides exposure during pregnancy. There are a number of pesticides that are thought to have teratogenic/mutagenic potential, and these and other commonly used pesticides are being studied in the San Joaquin Valley of California where there is heavy use of pesticides. The epidemiologic study design is case-control, where cases are fatal deaths that have been identified from certificates of fetal death and controls are live births randomly chosen (within matching variable strata) from the same counties. There are 644 cases of fetal death and 644 control births. The specific aims are as follows: 1) increase the questionnaire response rate by means of phone calls and mailings (the response rate to date for subjects for whom we have good addresses is 55%), 2) locate study subjects who we have not been able to contact due to outdated addresses on certificates of birth and fetal death (24% of the study subjects), 3) geocode the residential addresses during pregnancy for linkage to pesticide application data for restricted pesticides, 4) develop computer algorithms for determining sections adjacent to place of residence for the pesticide linkage (a section is a square mile unit within township and range), 5) code data on medical, environmental, and other factors that were collected on the questionnaire, and 6) analyze the relationship of low birth weight and pesticide exposure within the control group of live births.