Challenges to organocatalysis

该项目旨在利用有机催化来生成有机催化C=C插入、C-H官能化和羰基叶立德/1，3-偶极环加成反应。有机催化已经改变了进行化学合成的方式。然而，早些年，这门学科的重点主要是烯醇型化学，还没有考虑到更具挑战性的反应，如涉及类卡宾中间体的反应。在此之前，此类反应仅使用过渡金属催化剂实现。该项目解决了这一局限，使有机催化的优势(丰度和多样性、获得对映体纯度、元素的可持续性)影响到更广泛的催化图景。这种方法可以提供一个检查反应模式、立体选择性和级联设计的机会，并可能导致新的反应技术。

This project aims to use organocatalysis to generate organocatalytic C=C insertion, C-H functionalisation and carbonyl ylide/1,3-dipolar cycloaddition reactions. Organocatalysis has transformed the way chemical synthesis is performed. However, in the early years the focus of this discipline has primarily been enolate type chemistry, and more challenging reactions, such as those involving carbenoid intermediates, have not been contemplated. Previously such reactions have only been achieved using transition metal catalysts. This project addresses this limitation, allowing the strengths of organocatalysis (abundance and diversity, access to enantiopurity, elemental sustainability) to affect the broader landscape of catalysis. This approach could present an opportunity to examine reactivity patterns, stereoselectivity and cascade design and may lead to new reaction technologies.