DMSA, DMPS AND OTHER ORALLY ACTIVE DITHIOL CHELATORS

自1956年以来，BAL的水溶性类似物DMPS和DMSA取代了它 苏维埃和大陆中国医药中的螯合剂。与之类似的是 毒性小，口服有效。有关的有意义的信息 这些新药的新陈代谢和生物转化 西方世界，由于缺乏定量的分析技术 分析和/或识别它们是不存在的。我们计划开发高效液相色谱仪， GC/MS和其他分析方法对这些二巯基化合物及其 衍生品。一旦完成，我们将研究新陈代谢 DMPS、DMSA和DMPA的易损性和生物转化。此外， DMPS、DMSA、DMPA和WR2721的治疗效果将研究如下 慢性和急性铅中毒、顺铂(一种癌症)的解毒剂 化疗剂)肾毒性，并最终导致中毒 其他金属的化合物。金属硫蛋白的合成片段将是 在组织培养中作为亚砷酸钠的解毒剂进行了测试。实验在 哪些DMPS、DMSA和DMPA在同一时间或由 除了钠的案件外，不存在相同的调查小组 在首席调查员的实验室中进行的亚砷酸盐。 随着重金属对环境的污染日益严重，更好 金属粘结剂有待开发和研究。他们应该是 可帮助降低因环境原因引起的任何疾病的严重程度 重金属污染或任何其他重金属中毒。 体外和体内技术将被用来研究 被问到的问题。

Since 1956, DMPS and DMSA, water soluble analogs of BAL, have replaced this chelating agent in Soviet and mainland China medicine. The analogs are less toxic and are effective orally. Meaningful information about the metabolism and biotransformation of these agents, which are new to the western world, is lacking because analytical techniques for quantitatively assaying and/or identifying them is nonexistent. We plan to develop HPLC, GC/MS and other assays for these dimercapto compounds and their derivatives. Once this is done we shall investigate the metabolic liability and biotransformation of DMPS, DMSA and DMPA. In addition, the therapeutic effectiveness of DMPS, DMSA, DMPA and WR2721 will be studied as antidotes for chronic and acute lead poisoning, for cis-platinum (a cancer chemotherapy agent) renal toxicity and, eventually, for poisoning by compounds of other metals. A synthetic fragment of metallothionein will be tested in tissue culture as an antidote to sodium arsenite. Experiments in which DMPS, DMSA and DMPA have been compared at the same time or by the same investigative group are nonexistent except in the case of sodium arsenite as performed in the principal investigator's laboratory. With the increasing pollution of the environment by heavy metals, better metal binding agents need to be developed and studied. They should be available to help decrease the severity of any illness due to environmental pollution with heavy metals or to any other poisoning by heavy metals. Both in vitro and in vivo techniques will be used to investigate the questions being asked.