FUNCTIONAL ANATOMY OF PRIMATE EXTRASTRIATE VISUAL CORTEX

本提案中的实验旨在 视纹外肌的解剖和功能组织 灵长类动物的大脑皮层 一般有两套 实验，一个在人类皮层解剖学上，另一个在 猴子的功能组织。 在人体实验中，解剖的视觉皮层是扁平的， 切片并进行髓鞘、细胞色素氧化酶或 单克隆抗体CAT-301寻找解剖学同源物 猕猴皮层视觉区V2、V3、MT和LIP， V3 A和MST。 如果这种同源区域可以在 人类，这应该明确病因的具体感性 某些患者由于皮质损伤导致的缺损（例如Pearlman 等人，1979; Damasio等人，1980; zihl等人，1983）。 第二组实验中有三个实验， 猴子组织 所有这些实验都将使用光学 记录，双标记脱氧葡萄糖技术和/或 电生理标测，以证明和标测 功能架构 其中一个实验是针对 向MT区域移动，在那里将进行方向、速度 和其他类型的柱，以及内部差异 活动 另一个实验是对彩色列的测试 （波长偏好图）在任何皮质视觉区， 特别关注V1和V4领域。 在最后的实验中， 方向列将被标记在整个视觉皮层中， 新大陆和旧大陆的猴子 的存在或不存在 每个区域的方向列将作为 灵长类两科不同区域的同源性。

The experiments in this proposal are directed towards the anatomical and functional organization of extrastriate visual cortex in the primate. There are two general sets of experiments, one on human cortical anatomy, and the other on functional organization in the monkey. In the human experiments, autopsied visual cortex is flattened, sectioned and stained for either myelin, cytochrome oxidase, or the monoclonal antibody CAT-301 to look for anatomical homologues of macaque cortical visual areas V2, V3, MT and LIP, and perhaps V3A and MST. If such homologous areas can be demonstrated in the human, this should clarify the etiology of specific perceptual defects due to cortical damage in certain patients (e.g. Pearlman et al, 1979; Damasio et al, 1980; zihl eta al, 1983). There are three experiments int he scond set of experiments on monkey organization. All of these experiments will use optical recordings, the double-label deoxyglucose technique and/or electrophysiological mapping to demonstrate and map the functional architecture. One of these experiments is directed towards area MT, where tests will be done for direction, velocity and other types of columns, and for intrinsic differences in activity. Another experiment is a test for color columns (wavelength preference maps) in any cortical visual area, with special focus on areas V1 and V4. In the final experiment, orientation columns will be labelled throughout visual cortex, in both New and Old World monkeys. The presence or absence of orientation columns in each area will serve as a criteria for homology between different areas in the two families of primate.