AAFC IWYP Aligned Call; Circadian clock editing in wheat

该项目的总体目标是利用先进的生物技术、基因组学、功能基因组学和育种技术开发下一代小麦种质资源，以提高全球小麦生产的安全性，并解决到2050年遗传产量潜力增加50%的需求。据预测，全球变暖将增加气温和极端天气事件的频率，并改变降水模式和丰度，从而改变作物的水分供应。另一个直接后果是，许多地区的无霜天数将与南方地区的典型天数相当，但白天的长度将保持不变。因此，将光周期需求与生长季节相匹配是成功整合高产小麦基因型的关键。我们必须通过开发下一代种质资源来保护小麦生产，这些种质资源能够适应和抵御预期的多变气候条件。该项目将寻求产生和部署与IWYP目标相关的生物钟基因的遗传变异，以几种方式提高产量：我们将利用生物钟基因的力量来控制产量和应激反应。2. 我们将通过调节生物钟基因来优化生长，以提高产量和改善应激反应。3. 生物钟突变体（ccWheat）种质将被纳入AAFC和其他地方的小麦育种中。4. 将进一步开发突变育种工具、基因组编辑和控制重组的方法，以加快产量和胁迫反应的育种。

The overall aim of this project is to utilize advanced biotechnology, genomics, functional genomics, and breeding techniques to develop next-generation wheat germplasm that will increase the security of global wheat production and address the need for a 50% increase in genetic yield potential by 2050 (IWYP). Global warming is predicted to increase temperature and the frequency of extreme weather events, and also to alter precipitation patterns and abundance, thus changing water availability to crops. Another direct consequence is that the number of frost-free days in many regions will become comparable to what is typical of more southern regions, however the day length will remain unchanged. For this reason, alignment of photoperiodic requirements with the growing season is key to the successful integration of high yielding wheat genotypes. It is imperative that we protect wheat production by developing next-generation germplasm that is adaptable and resilient to anticipated variable climatic conditions. This project will seek to generate and deploy genetic variation in circadian clock genes with relevance to IWYP aims of increasing yield in several ways: 1. We will harness the power of circadian clock genes in controlling yield and stress responses. 2. We will optimize growth through modulation of circadian clock genes for yield increase and improved stress responses. 3. The circadian clock mutant (ccWheat) germplasm will be incorporated into wheat breeding at AAFC and elsewhere. 4. Mutational breeding tools, genome editing and methods to control recombination, will be further developed for accelerating breeding for yield and stress responses.