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THE CHEMISTRY OF NATURAL PRODUCTS

THE CHEMISTRY OF NATURAL PRODUCTS
天然产物的化学原理
批准号:
3268040
负责人:
GEORGE H BUCHI
金额:
$28.15万
依托单位国家:
美国
项目类别:
财政年份:
1977
资助国家:
美国
项目状态:
已结题
起止时间:
1977-04-01 至 1987-03-31

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中文摘要
翻译
海洋产品单溴溴和双溴法凯林将通过一种 生物遗传模式的路线。在一项相关的研究中,合成了一种 对麻风性贝类毒素进行了研究。米瑞斯特罗一种植物 不属于类固醇的雌激素正在被合成。麦角酸 一些相关化合物是几种药物的结构单元。一个 生物模式合成麦角酸及其相关麦角林 正在开发中。人们正在尝试将双萘醌类化合物 到含有以下基本环结构的分子内Aldol产物 萘环酮类抗生素。一种生物发生的推测方案 的硫代阿司匹林生物碱正在进行实验测试。一种新的 将合成寄生曲霉产生的抗生素。
英文摘要
The marine products monobromo and dibromphakellin will be synthesized by a biogenetically patterned route. In a related study a synthesis of the paralytic shellfish poison saxitoxin is investigated. Mirestrol a plant estrogen not belonging to the steriods is being synthesized. Lysergic acid and some related compounds are structural units of several drugs. A biogenetically patterned synthesis of lysergic acid and related ergolines is being developed. Attempts are being made to convert bisnaphthoquinones to intramolecular aldol products containing the basic ring structures of the naphthocyclinone antibiotics. A speculative scheme for the biogenesis of the thiaspirane alkaloids is being tested experimentally. A new antibiotic produced by Aspergillus parasiticus will be synthesized.
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