THE CHEMISTRY OF NATURAL PRODUCTS

海风藤酮，中国草药植物海风藤的一种成分 黑粉藤是一种强效、特异性的血小板活化因子（PAF） 拮抗剂 一种短而有效的海风藤酮的合成方法正在研究中。 开发 在这项工作中获得的经验将用于综合 美雌酚一种天然雌激素 毛果芸香碱是一种临床上 使用抗青光眼药。 目前从毛果芸香属中分离得到 joborandi，一种正在迅速消失的热带树木。 全面综合 对映体和立体化学纯的毛果芸香碱是在 调查 长春碱和长春新碱是有用的，但非常昂贵 抗肿瘤剂。 由天然文多灵和苯并咪唑合成文多灵的新方案 将对完全合成的组分进行实验测试。 阿尔乔宁和 异alchorneine，两种甲氧基胍生物碱用于中非 治疗各种疾病的民间药物。 这两名特工似乎没有 通过现代药理学方法进行了研究。 全合成工作 已经开始了。

Kadsurenone, a constituent of the Chinese herbal plant Piper futokadsura (heifenteng) is a potent and specific platelet activating factor (PAF) antagonist. A short and efficient synthesis of Kadsurenone is being developed. Experience gained in this work will be used to synthesize mirestrol, a naturally occurring estrogen. Pilocarpine is a clinically used antiglaucoma agent. It is presently isolated from Pilocarpus jaborandi, a rapidly disappearing tropical tree. A total synthesis of enantiomerically and stereochemically pure pilocarpine is under investigation. Vinblastine and vincrystine are useful but very expensive antitumor agents. A new synthetic scheme from natural vindoline and a totally synthetic component will be tested experimentally. Alchorneine and isoalchorneine, two methoxyguanidine alkaloids are used in Central African folk medicine for various ailments. The two agents do not seem to have been examined by modern pharmacological methods. Work on total syntheses has been initiated.