THE CHEMISTRY OF NATURAL PRODUCTS

海风藤酮--中草药海风藤的成分 (合芬腾)是一种强效、特异的血小板活化因子(PAF) 对抗者。一种短而有效的海风藤酮的合成正在进行中 发展起来的。在这项工作中获得的经验将被用来综合 米瑞斯特罗，一种自然产生的雌激素。匹罗卡品是一种临床上的 使用过的抗青光眼药物。它目前是从毛果属植物中分离出来的 哈博兰迪，一种迅速消失的热带树木。全合成的 对映体和立体化学纯的毛果芸香碱 调查。长春花碱和长春花碱是有用的，但非常昂贵 抗肿瘤药物。一种以天然长春花碱为原料的合成新方案 完全合成的部件将在实验中进行测试。Alclneine和 中非使用的是异山梨碱、两种甲氧基胍类生物碱 治疗各种疾病的民间药物。这两名特工似乎没有 用现代药理学方法进行了检测。关于全合成的工作 已经启动了。

Kadsurenone, a constituent of the Chinese herbal plant Piper futokadsura (heifenteng) is a potent and specific platelet activating factor (PAF) antagonist. A short and efficient synthesis of Kadsurenone is being developed. Experience gained in this work will be used to synthesize mirestrol, a naturally occurring estrogen. Pilocarpine is a clinically used antiglaucoma agent. It is presently isolated from Pilocarpus jaborandi, a rapidly disappearing tropical tree. A total synthesis of enantiomerically and stereochemically pure pilocarpine is under investigation. Vinblastine and vincrystine are useful but very expensive antitumor agents. A new synthetic scheme from natural vindoline and a totally synthetic component will be tested experimentally. Alchorneine and isoalchorneine, two methoxyguanidine alkaloids are used in Central African folk medicine for various ailments. The two agents do not seem to have been examined by modern pharmacological methods. Work on total syntheses has been initiated.