19-ERACoBioTech- 33 SyCoLim

ERA CoBioTech寻求从石油经济向生物循环经济的转变，这可以通过开发微生物生物生产工艺等新型生物技术来实现。该项目（SyCoLim）的目的是生产高价值的化学品（应用于药物、药品、香料、保健品或化妆品）（回收甘油，生物柴油工业的副产品）。为了实现这一目标，将创建酵母和细菌之间的合成微生物群落。这些社区将被设计成比单一栽培更有优势，例如分工、更高的适应性和鲁棒性或扩大的代谢网络。由最佳菌株进行的生物工艺将在我们的工业合作伙伴的设施中在工业条件下扩大规模。因此，该项目将有助于有价值化合物的可持续生产从实验室到市场的过渡，并将联合收割机与探索新的合成生物学和微生物群落方法相结合，这些方法有可能适用于其他生物过程，从而促进全球向生物经济的过渡。SyCoLim的合作伙伴经过精心挑选，尽可能符合项目的基本原理，不仅在技能和方法方面，而且在合成微生物群落的先前经验方面。因此，学术合作伙伴是世界领先的酵母和细菌工程研究人员，在使用合成生物学创建微生物群落，在尖端分析（包括代谢组学和蛋白质组学）和建模社区。此外，该工业合作伙伴是少数几家在使用工程微生物群落的商业过程中拥有专业知识的生物技术公司之一。科学工作包将与负责任的研究和创新计划并行开发，该计划旨在评估该过程的环境和社会方面，并将指导实验计划和结果。SyCoLim还致力于严格的道德和数据管理标准，拥抱公平原则。该项目伴随着一个坚实的沟通和传播计划，以达到不同的利益相关者，并最大限度地提高项目成果的影响。该项目将得到认真管理，以优化合作伙伴的平等参与、适当的预算、性别平衡、风险评估、备份战略、有效的沟通以及团队之间的人员和物资转移。

ERA CoBioTech seek the transition from a petroleum-based economy to a bio-based, circular economy, which can be achieved by the development of novel biotechnologies such as microbiological bioproduction processes.The aim of this project (SyCoLim) is to produce high-value chemicals (with applications as pharmaceuticals, medicines, fragrances, nutraceuticals or cosmetics) from waste raw materials (recycling glycerol, the by-product of biodiesel industries). In order to achieve this objective, synthetic microbial communities between yeast and bacteria will be created. These communities will be engineered to present advantages over monocultures, such as division of labour, higher adaptability and robustness or an expanded metabolic network. The bioprocess carried out by the best strains generated will be scaled up in industrial conditions in the facilities of our industrial partner. Therefore, the project will help the lab-to-market transition of the sustainable production of valuable compounds and will combine this with the exploration of novel synthetic biology and microbial communities' methodologies that have the potential to be applicable to other bioprocesses, thus facilitating the global transition towards the bioeconomy.The partners of SyCoLim has been selectively chosen to be the best fit possible to the rationale of the project, in terms not only of skills and methodologies but also in previous experience in synthetic microbial communities. Thus, together, the academic partners are world-leading researchers in yeast and bacteria engineering, in using synthetic biology to create microbial communities, in cutting-edge analytics (including metabolomics and proteomics) and in modelling communities. In addition, the industrial partner is one of the few biotech companies with expertise in commercial processes using engineered microbial communities. The scientific work packages will be developed in parallel to a Responsible Research an Innovation plan intended to evaluate the environmental and societal aspect of the process and it will guide and be guided by the experimental plans and results. SyCoLim is also committed to strict ethics and data management standards, embracing the FAIR principles. The project is accompanied by a solid Communication and Dissemination plan to reach different stakeholders and maximise the impact of the project's outcomes. The project will be carefully managed to optimise equal participation of the partners, appropriate budgets, gender balance, risk assessment, back up strategies, efficient communication and personnel and material transfer between teams.