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MOLECULAR APPROACHES TO CELL ULTRASTRUCTURE

MOLECULAR APPROACHES TO CELL ULTRASTRUCTURE
细胞超微结构的分子方法
批准号：
3268876
负责人：
S J SINGER
金额：
$35.38万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN DIEGO
依托单位国家：
美国
项目类别：
财政年份：
1978
资助国家：
美国
项目状态：
已结题
起止时间：
1978-05-01 至 1991-04-30
来源：
https://reporter.nih.gov/project-details/3268876
关键词：
autoradiography binding proteins brush border membrane cell cell interaction cell membrane cell type chemical models chickens cytoskeleton electron microscopy fibroblasts fluorescent dye /probe glycoproteins guinea pigs histochemistry /cytochemistry hybridomas immunochemistry immunoelectron microscopy immunofluorescence technique laboratory mouse laboratory rabbit laboratory rat lymphocyte membrane activity membrane permeability membrane proteins membrane reconstitution /synthesis membrane structure microfilaments microtubules molecular rearrangement monoclonal antibody muscle proteins neoplastic transformation pinocytosis protein metabolism protein structure radiotracer stainings surface antigens temperature sensitive mutant tissue /cell culture

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中文摘要
翻译
我们将开展以下几个项目：1)高分辨率免疫电子
英文摘要
We will carry out several projects: 1) the high resolution immunoelectron microscopic localization of a number of recently discovered junctional proteins at a variety of membrane - microfilament attachment sites; 2) continued search for integral membrane proteins at these sites, using a monoclonal antibody approach combined with selection by immunocytochemical localization; 3) continued studies of the immunolocalization of phosphotyrosine residues of proteins inside intact cells, using specific monoclonal antibodies generated to phosphotyrosine; 4) the extension of our immunoelectron microscopic studies of the intracellular pathways of serum protein secretion in cultured hepatocytes; and 5) the exploration of the molecular basis for the association which we have demonstrated between the Golgi apparatus and the microtubule organizing center in cells.
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