MEIBOMIAN GLAND DYSFUNCTION IN CHRONIC BLEPHARITIS

我们的目标是了解慢性睑缘炎，睑板的作用 睑缘炎中睑板腺的变化及睑板腺缺失对睑缘炎的影响 眼部蒸发的动力学。 我们假设睑板腺 在某些形式的慢性睑缘炎中发生的损失导致改变的 睑板腺功能，眼表蒸发增加， 和增加的泪液渗透压。 通过对所获得数据的仔细分析， 对于这些睑缘炎患者，我们也希望能够达到更好的下， 睑缘炎亚群的特征和 睑板腺功能（腺体脱落、体积） 和粘度）和蒸发状态（泪液蒸发，渗透压， 泪流满面）。 为了实现这些目标，我们将通过以下方式来检验我们的假设 具体目的：1）建立正常睑板腺的范围 对150例不同年龄组患者的眼球蒸发状态进行了观察 好几年了 我们将测量五个定量变量：睑板腺 脱落率、蒸发率、泪液渗透压和泪液流量（通过荧光显微镜）， tometry和两个定性变量：排泄物体积和粘度。（二） 我们将在150例患者中建立睑板腺功能的范围 慢性睑缘炎测量相同的变量，并使用相同的 年龄和性别分布。3)我们将确定 蒸发率和腺体脱落，泪液渗透压，泪液流量和分泌， 在这150名慢性睑缘炎患者中， 上面收集的数据。4)我们将研究诱导 由全身性异维A酸引起的睑板腺功能障碍（accu， tane）对泪液蒸发、渗透压和泪液流量的影响， 通过测量这些相同的变量，对30名患者进行治疗后。5)我们 将使用我们的数据来更好地表征包括BLE的子集， 通过对收集的大数据库进行聚类分析， 从这150名睑缘炎患者身上。

Our goal is to understand chronic blepharitis, the role of the meibomian gland in blepharitis and the effect of meibomian gland loss on the dynamics of ocular evaporation. Our hypothesis is that meibomian gland loss, which occurs in some forms of chronic blepharitis, leads to altered meibomian gland function, increased evaporation from the ocular surface, and increased tear osmolarity. By careful analysis of the data obtained on these blepharitis patients, we also hope to achieve a better under- standing of the characteristics of the blepharitis subsets and of the interrelationship between meibomian gland function (gland dropout, volume and viscosity) and the evaporative state (tear evaporation, osmolarity, and tear flow). To achieve these goals we will test our hypothesis by the following specific aims: 1) We will establish the range of normal meibomian gland function on the evaporative state of the eye for 150 patients over a rang in ages. We will measure five quantitative variables: meibomian gland dropout, evaporation rate, tear osmolarity, and tear flow by fluoropho- tometry, and two qualitative variables: excreta volume and viscosity. 2) We will establish the range of meibomian gland function in 150 patients with chronic blepharitis measuring the same variables and using the same age and sex distribution. 3) We will determine the correlation between evaporation rate and gland dropout, tear osmolarity, tear flow and excre- ta volume and viscosity in these 150 chronic blepharitis patients using the data collected above. 4) We will investigate the effect of induced meibomian gland dysfunction resulting from systemic Isotretinoin (accu- tane) on tear evaporation, osmolarity, and tear flow before, during and after treatment in 30 patients by measuring these same variables. 5) We will use our data to characterize better the subsets which comprise ble- pharitis by applying cluster analysis to the large data base collected from these 150 patients with blepharitis.