MEIBOMIAN GLAND DYSFUNCTION IN CHRONIC BLEPHARITIS

我们的目标是了解慢性眼缘炎，眉毛的作用 睑缘炎中的汗腺及眉板腺缺失对眼睑功能的影响 眼睛蒸发的动力学。我们的假设是眉毛腺 丢失，这发生在某些形式的慢性眼缘炎，导致改变 眉毛腺功能，眼表蒸发增加， 并增加了泪液渗透压。通过对获得的数据进行仔细的分析 对这些眼缘炎患者，我们也希望达到更好的下- 眼睑炎亚组和眼睑炎组特征的认识 眉板腺功能(腺脱落、体积)之间的相互关系 和粘度)和蒸发状态(泪液蒸发、渗透压、 和泪水流动)。 为了实现这些目标，我们将通过以下方式来验证我们的假设 具体目标：1)建立正常眉板腺的范围 150例患者眼部蒸发状态的检测结果分析 在很久以前。我们将测量五个数量变量：眉板腺 脱落率、蒸发率、泪液渗透压和荧光法测定的泪液流量 和两个定性变量：排泄物体积和粘度。2) 我们将确定150例患者的眉板腺功能范围。 慢性眼睑炎测量相同的变量并使用相同的 年龄和性别分布。3)我们将确定两者之间的相关性 蒸发率和腺体脱落，泪液渗透压，泪液流量和过敏性。 150例慢性眼睑炎术前、术后的TA体积和黏度测定 以上收集的数据。4)我们将调查诱因的影响 全身性异维A酸所致的汗腺功能障碍 Tane)对泪液蒸发、渗透压和泪液流动的影响 治疗后30例患者通过测量这些相同的变量。5)我们 将使用我们的数据来更好地表征组成ble-的子集 将聚类分析应用于收集的大型数据库中的咽炎 从这150名眼缘炎患者中。

Our goal is to understand chronic blepharitis, the role of the meibomian gland in blepharitis and the effect of meibomian gland loss on the dynamics of ocular evaporation. Our hypothesis is that meibomian gland loss, which occurs in some forms of chronic blepharitis, leads to altered meibomian gland function, increased evaporation from the ocular surface, and increased tear osmolarity. By careful analysis of the data obtained on these blepharitis patients, we also hope to achieve a better under- standing of the characteristics of the blepharitis subsets and of the interrelationship between meibomian gland function (gland dropout, volume and viscosity) and the evaporative state (tear evaporation, osmolarity, and tear flow). To achieve these goals we will test our hypothesis by the following specific aims: 1) We will establish the range of normal meibomian gland function on the evaporative state of the eye for 150 patients over a rang in ages. We will measure five quantitative variables: meibomian gland dropout, evaporation rate, tear osmolarity, and tear flow by fluoropho- tometry, and two qualitative variables: excreta volume and viscosity. 2) We will establish the range of meibomian gland function in 150 patients with chronic blepharitis measuring the same variables and using the same age and sex distribution. 3) We will determine the correlation between evaporation rate and gland dropout, tear osmolarity, tear flow and excre- ta volume and viscosity in these 150 chronic blepharitis patients using the data collected above. 4) We will investigate the effect of induced meibomian gland dysfunction resulting from systemic Isotretinoin (accu- tane) on tear evaporation, osmolarity, and tear flow before, during and after treatment in 30 patients by measuring these same variables. 5) We will use our data to characterize better the subsets which comprise ble- pharitis by applying cluster analysis to the large data base collected from these 150 patients with blepharitis.