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MOLECULAR APPROACHES TO CELL ULTRASTRUCTURE

MOLECULAR APPROACHES TO CELL ULTRASTRUCTURE
细胞超微结构的分子方法
批准号:
3268871
负责人:
S J SINGER
金额:
$23.08万
依托单位国家:
美国
项目类别:
财政年份:
1978
资助国家:
美国
项目状态:
已结题
起止时间:
1978-05-01 至 1995-04-30

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中文摘要
翻译
这项研究计划的长期目标是探索 许多不同细胞现象的分子基础,所有这些 都有共同之处,都涉及细胞膜。要解决的具体问题 被调查,这是我们过去对这笔赠款研究的结果, 包括以下内容:1)细胞内转运的机制 从内质网到内质网的分泌和整合膜蛋白 高尔基体;2)新发现的膜结合酪氨酸的作用 在鸡胚胎中的重要组成部分,在胚胎中 发展;3)跨膜的信号转导机制 导致细胞内大量的细胞质重排和极化 受影响的细胞。
英文摘要
The long-term objectives of this research program are to explore the molecular bases of a number of different cellular phenomena, all of which have in common the involvement of cell membranes. The specific problems to be investigated, which are outgrowths of our past studies on this grant, include the following: 1) the mechanisms of intracellular transport of secretory and integral membrane proteins from the endoplasmic reticulum to the Golgi apparatus; 2) the role of newly discovered membrane-bound tyrosin kinases, which are prominent components in the chick embryo, in embryonic development; 3)the mechanisms of signal transduction across membranes that result in massive cytoplasmic rearrangements and polarization inside the affected cells.
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