GENETIC CONSEQUENCES OF POPULATION STRUCTURE

这项拟议研究的总体目标是了解 物种进化过程中的种群结构。人口结构 是繁殖个体在内部和之间的分布方式 德米斯和他们在德米斯人中的运动模式。人口细分 既有生态后果又有遗传后果。的遗传效应 随机遗传漂移会导致阵列的遗传分化 当地的德米斯人。遗传分化的速度和程度取决于 本地繁殖成虫的数量和数量和格局 分散在当地人中间，德梅斯人。细分的生态效应 影响德米斯人内部和之间的选择过程。生态化 而遗传效应相互作用决定了Intra基因的相对重要性 和间种选择对物种整体进化的影响。我们是 结合实验研究，使用面粉的实验室种群 甲虫(Tribolium属)，以及相关遗传的理论模型 现象来研究这些类型的种群结构 可能会对一个物种产生重要的进化后果。 进化是结构化的，人口是赖特的中心特征 进化论中最全面的平衡转移理论之一 遗传学和进化论。拟议的研究将提供一个 赖特理论的实验基础，特别强调 基因相互作用在适应性进化的“间性阶段”中的作用。

The overall objective of the proposed research is to understand the role of population structure in the evolution of a species. Population structure is the way in which breeding individuals are distributed within and among demes and their pattern of movement among demes. Population subdivision has both ecological and genetic consequences. The genetic effects of random genetic drift can result in the genetic differentiation of an array of local demes. The rate and degree of genetic differentiation depend on the numbers of locally breeding adults and the amount and pattern of dispersion among locals demes. the ecological effects of subdivision influence the process of selection within and among demes. The ecological and genetic effects interact to determine the relative importance of intra and interdemic selection to the overall evolution of the species. We are combining experimental studies, using laboratory populations of flour beetles (genus Tribolium), with theoretical models of the relevant genetic phenomena to investigate those kinds of population structures that are likely to have important evolutionary consequences for a species. Evolution is structured population is the central feature of Wright's Shifting Balance Theory of Evolution, one of the most comprehensive theories of genetics and evolution. The proposed research will provide an experimental foundation for Wright's theory with special emphasis on the role of gene interactions in the "interdemic-phase" of adaptive evolution.