COMPUTER-ASSISTED ANALYSIS OF CHEMICAL SYNTHESIS

这项工作的主要目标是数字计算机的应用 到复杂有机结构的合成途径的推导。 一个通用问题解决程序，拉萨(应用逻辑和启发式 到综合分析)，正在开发中，可用于 由化学家通过简单的图形输入-输出 结构公式。有机合成的原则和策略 正被正规化以供该计划使用。各种策略 包括远程搜索功能在内的 程序。此外，关于人工合成的大量信息 化学正在被组织和合理化，以提供丰富和 有效的知识库。该程序可用于解决问题 涉及具有生物重要性的物质，并可供其他 科学家。拉萨项目开创了计算机辅助技术领域的先河 综合分析。拉萨一直是并将继续是世界上 用于综合分析的复杂而强大的计算机程序。我们的 目标是大幅提高拉萨的能力，使其成为 这是一种有价值且被广泛使用的科学工具。

The major objective of this work is the application of digital computers to the derivation of synthetic pathways to complex organic structures. A general problem-solving program, LHASA (Logic and Heuristics Applied to Synthetic Analysis), is being developed which can be used interactively by a chemist with simple graphical input-output of structural formulas. The principles and strategies of organic synthesis are being formalized for use by the program. A variety of strategies including long-range search capabilities are being employed in the program. In addition, the vast range of information on synthetic chemistry is being organized and rationalized to provide a rich and effective knowledge base. The program can be applied to problems involving biologically important substances and is available to other scientists. The LHASA project pioneered the field of computer-assisted synthetic analysis. LHASA has been and continues to be the most sophisticated and powerful computer program for synthetic analysis. Our goal is to increase greatly the capabilities of LHASA so that it becomes a valuable and widely used tool in science.