Intracellular Nanovesicles: their formation, transport and cargo

人类是由许多细胞组成的。每个细胞的内部都是一个忙碌的世界，而不是无聊的积木，蛋白质在这里被制造并开始工作，不断地四处移动。这允许每个细胞吃，喝，繁殖等等。我们感兴趣的是细胞的膜运输系统：一个由不同类型的膜囊泡组成的运输网络，重要的蛋白质可以在其中旅行。膜运输确保货物蛋白在正确的时间到达正确的位置。这使细胞保持健康和正常的功能。我们最近发现了一种新型的囊泡，现在我们想更详细地了解它。这些囊泡被称为细胞内纳米囊泡，或简称INV。在细胞中，当囊泡形成时，它会收集它将要吸收的蛋白质，并从其来源发芽。然后它必须被运送到目的地，在那里它与靶膜融合。你可以把这看作是囊泡的生命周期：它们出生，旅行，然后在运送重要货物时死亡。在这个项目中，我们想记录投资者的生活故事。我们将关注他们的“早年”。他们是怎么出生的？他们怎么旅行？他们带着哪些朋友一起走沿着？人们对INVs知之甚少，因为它们是最近才发现的。INVs生命故事的细节可能会改变细胞生物学家对膜交通系统的看法。

Humans are built from lots of cells. Rather than being boring building blocks, the interior of each cell is a busy world where proteins are made and go to work, constantly moving around. This allows each cell to eat, drink, reproduce, and much more. We are interested in the cell's membrane trafficking system: a transport network of different types of membrane vesicles that important proteins can travel in. Membrane trafficking ensures that cargo proteins go to the right place at the right time. This keeps cells functioning healthily and normally. We recently found a new type of vesicle and we now want to understand it in more detail. These vesicles are called intracellular nanovesicles, or INVs for short. In cells, when a vesicle is formed, it gathers the proteins that it will take and buds from its origin. It must then be transported to its destination where it fuses with the target membrane. You can think of this as the vesicle's life cycle: they are born, they travel and then they die when they deliver their important cargo. In this project we want to document the life story of INVs. We will focus on their "early years". How are they born? How do they travel? Which friends do they carry along the way? Very little is known about INVs because they were only recently discovered. The details of the life story of INVs is likely to change how cell biologists think about the membrane traffic system.