CHIRAL APPROACHES TO NATURAL PRODUCT SYNTHESIS

拟议的研究涉及研究和开发一种 各种碳-碳键形成反应，它们是 特别适合用于合成天然的 具有理想的抗生素或抗肿瘤活性的产品；以及 这些方法在此类化合物的全合成中的应用 化合物。具体例子包括抗生素，如 胶原二醇、钙霉素、卡霉素和泰乐菌素，以及 抗肿瘤药物赫比霉素。一项综合性的调查研究 非常有希望的根霉毒素家族的抗肿瘤药物，设计没有 不仅最终在实验室成功合成，而且还 揭示活动所需的结构特征，并提供 更简单的生物活性类似物，也被建议作为 举例说明这种方法如何实现特别简明 生物重要化合物的合成。

The proposed research involves the study and development of a variety of carbon-carbon bond forming reactions which are particularly well suited for use in the synthesis of natural products possessing desirable antibiotic or antitumor activity, and the application of these methods to total syntheses of such compounds. Specific examples include antibiotics such as colletodiol, calcimycin, carbomycin and tylosin, as well as the antitumor agent herbimycin. A synthetic investigation of the very promising rhizoxin family of antitumor agents, designed not only to culminate in a successful laboratory synthesis but also to reveal structural features required for activity and to provide simpler biologically active analogues, is also proposed as an example of how such methodology allows for particularly concise syntheses of biologically important compounds.