What's the Risk from and to European wildlife from SARS-like Coronaviruses?

目前的COVID-19人类大流行起源于东南亚野生动物，尽管天然的地方性宿主仍然未知（最有可能是蝙蝠），但从人类传播到其他物种，包括养殖水貂的大规模爆发和家猫的病例不断发生。在欧洲和美国的水貂中爆发并传播回人类，这引起了病毒在其他动物宿主中建立自身的幽灵，为病毒创造了一个新的宿主，对人类和受影响的动物都可能造成严重后果。欧洲是大量野生鼬科动物的家园，包括野生水貂，沿着已知携带SARS样病毒的蝙蝠和被认为易感染SARS-CoV 2的啮齿类动物。然而，我们目前不知道这些动物中是否发生任何病毒溢出或循环。该项目将在英国对来自最高风险野生动物物种的粪便和肺样本进行基于PCR的SARS-CoV-2样病毒筛查（蝙蝠、鼬科动物和仓鼠科啮齿动物），包括使用NGS测序技术从任何阳性动物中检索完整病毒序列（Illumina和Nanopore）。该项目将确定：a）如果目前正在发生SARS-COV-2从人类向野生动物的蔓延b）这些动物携带的其他冠状病毒这将有助于决定SARS-CoV-2在欧洲野生动物中的传播是否对人类和/或野生动物构成真实的风险，以及是否需要监测或缓解方案

The current COVID-19 human pandemic had its origins in SE Asian wildlife, and although the natural, endemic host remains unknown (most likely bats), onward transmission from humans to other species including large outbreaks in farmed mink and cases in domestic cats keep occuring . The outbreak in mink in Europe and the USA with transmission back to humans has raised the spectre of the virus establishing itself in other animal hosts, creating a new reservoir for the virus, with potentially serious consequences for both humans and affected animals. Europe is home to a large number of wild mustelid species, including feral mink, along with bats known to carry SARS-like viruses and cricetid rodents thought to be susceptible to SARs-CoV2. However, we currently have no idea whether any virus spill-over or circulation is occurring in these animals. This project will perform PCR based screening of faecal and lung samples from the highest risk wildlife species for SARS-CoV-2 like viruses in the UK (bats, mustelids and cricetid rodents), including retrieval of full virus sequences from any positive animals using NGS sequencing techniques (Illumina and Nanopore).The project will determine:a) If SARS-COV-2 spill-over from humans into wildlife is currently occurringb) What other coronaviruses these animals are carryingThis will enable decisions to be made as to whether SARS-CoV-2 circulation in European wildlife represents a real risk to the human population and/or to wildlife, and if monitoring or mitigation programmes are necessary