BIOLOGICALLY ACTIVE COMPOUNDS VIA CHIRAL AROMATICS

建议继续进行研究，在这些研究中 恶唑啉(苯基、萘基)被用来在 立体专一性方式，通过加成两个或更多手性中心 芳香的环。选择适当的亲核试剂 和捕获亲电体，我们希望能达到各种 重要的自然发生的、生物活性的系统。这 研究将提供(+)-阿拉维酮，(-)-鬼臼毒素， 和(+)-硬脂酮，以及合成的关键中间体 百菌清和拉沙洛西德A.对其他系统的扩展 为了评估这些立体化学过程的范围，还 想象中的。 此外，含手性恶唑啉的杂环芳烃 将研究以对映体选择性地将取代基引入 吡啶环。这些反应的产物将作为 NADH模拟模型和高选择性手性模型 还原剂。我们将研究这些自焚过程，以 加强对各种因素影响的进一步了解 影响高不对称还原的参数 不同的前手性底物。

Studies are proposed to continue efforts in which aromatic oxazolines (phenyl, naphthyl) are utilized to introduce, in a stereospecific manner, two or more chiral centers by addition to the aromatic ring. With the appropriate choice of nucleophiles and trapping electrophiles, we hope to reach a variety of important naturally occurring, biologically active systems. This study will provide access to (+)-aklavinone, (-)-podophyllotoxin, and (+)-steganone, and key intermediates for the synthesis of chlorothricolide and lasalocid A. Extensions to additional systems to evaluate the scope of these stereochemical processes are also envisioned. Furthermore, heterocyclic aromatics containing chiral oxazolines will be studied to introduce substituents, enantioselectively, into the pyridine ring. The products of these reactions will serve as models for NADH mimics and also as highly selective chiral reducing agents. We will study those self-immolative processes to enhance the further understanding of the effects of various parameters which are responsible for high asymmetric reduction of various prochiral substrates.