APPROACHES TO COMPLEX CHIRAL QUATERNARY CARBON COMPOUNDS

继续研究手性双环化合物用途的计划 内酰胺类化合物作为多种对映体纯品的有价值的前体 物质被提出。这项始于1985年的研究表明， 在这些手性模板上进行的各种反应导致 多种季碳化合物的高效合成 重要的生物活性材料。 目前的建议将把这些研究扩大到目前为止 未见文献报道的手性吡咯烷、八烷酮、[3，3，0]二环烯酮、 螺环戊烯酮以及有用的环丙烷氨基酸， 异喹啉、胺和其他--都是高对映体纯度。AS 这一不对称方法的演示，合成路线到 概述了一些具有药学意义的系统。

A program to continue studies on the use of chiral bicyclic lactams as valuable precursors to a variety of enantiomerically pure substances is presented. This study, which began in 1985, has shown that a variety of reactions performed on these chiral templates lead to efficient syntheses of quaternary carbon compounds found in many important biologically active materials. The present proposal will extend these studies to heretofore unreported chiral pyrrolidines, octalones, [3,3,0] bicyclic enones, spirocyclopentenones as well as useful cyclopropane amino acids, isoquinolines, amines, and others - all in high enantiomeric purity. As a demonstration of this asymmetric methodology, synthetic routes to a number of pharmaceutically significant systems are outlined.