COORDINATION OF CELL GROWTH AND DIVISION

细胞周期是细胞生长、复制、繁殖和再生的一系列过程 它的DNA和分裂 在平衡增长的过程中， 新的细胞成分--酶， 结构蛋白、细胞膜、核糖体、DNA--以及 单元格：在某种平均意义上，每个组件必须在单元格期间加倍 循环，然后在两个子细胞之间公平地分配。 是 通常认为这种配位是通过分子 感知细胞大小总体增加并触发细胞 当达到目标尺寸时，分裂，当然，前提是DNA是 完全复制。 本提案的具体目的是调查 细胞分裂大小控制假说 模型机制的性质和比较这些理论性质 通过对异步增殖细胞的实验观察 cultures. 作为分裂控制机制的一部分， 通过现代分子和基因技术发现， 所提出的理论方法获得的将是有价值的， 一起完整了解细胞生长的调控系统， 师. 由于细胞生长和分裂是细胞生长的基本过程， 医学科学的几个领域（例如，肿瘤生长，发育的 疾病和病原微生物的传播），基础研究 基础监管机制对国家利益至关重要， 健康

The cell cycle is the sequence of events whereby a cell grows, replicates its DNA and divides. During balanced growth there must be some coordination between the synthesis of new cell components--enzymes, structural proteins, membranes, ribosomes, DNA--and the division of a cell: in some average sense, each component must double during the cell cycle and then be fairly divided between the two daughter cells. It is commonly assumed that this coordination is achieved by a molecular mechanism that senses overall increase in cell size and triggers cell division when a target size is reached, provided of course that DNA is fully replicated. The specific aim of this proposal is to investigate the hypothesis of size-control of cell division by deriving statistical properties of model mechanisms and comparing these theoretical properties with experimental observations of asynchronous, proliferating cell cultures. As bits and pieces of the division-control mechanism are discovered by modern molecular and genetic techniques, the experience gained by the proposed theoretical approach will be valuable in putting together a complete picture of the regulatory system for cell growth and division. Since cell growth and division are fundamental processes in several areas of medical science (e.g., tumor growth, developmental disorders, and the spread of pathogenic microorganisms), basic research on the underlying regulatory mechanisms is vital to the interests of national health.