COORDINATION OF CELL GROWTH AND DIVISION

细胞周期是细胞生长、复制的一系列事件 它的DNA和分裂。在平衡增长期间，一定会有一些 新细胞成分的合成之间的协调--酶， 结构蛋白、膜、核糖体、DNA--以及 单元格：在某种平均意义上，每个组件在单元格期间必须加倍 循环，然后在两个子细胞之间公平分配。它是 通常假设这种协调是由一个分子实现的 感知细胞大小总体增加并触发细胞的机制 当达到目标大小时进行除法运算，当然前提是DNA 完全复制。这项建议的具体目的是调查 细胞分裂大小控制的统计推导假说 模型机构的性质及其理论性质的比较 通过实验观察到异步化、增殖的细胞 文化。由于分割控制机构的零碎部件 通过现代分子和基因技术发现，这一经历 通过建议的理论方法获得的结果将在 共同描绘了细胞生长和调控系统的完整图景 组织。因为细胞的生长和分裂是 医学的几个领域(例如，肿瘤生长、发育 疾病和致病微生物的传播)，基础研究 基本的监管机制对国家利益至关重要 健康。

The cell cycle is the sequence of events whereby a cell grows, replicates its DNA and divides. During balanced growth there must be some coordination between the synthesis of new cell components--enzymes, structural proteins, membranes, ribosomes, DNA--and the division of a cell: in some average sense, each component must double during the cell cycle and then be fairly divided between the two daughter cells. It is commonly assumed that this coordination is achieved by a molecular mechanism that senses overall increase in cell size and triggers cell division when a target size is reached, provided of course that DNA is fully replicated. The specific aim of this proposal is to investigate the hypothesis of size-control of cell division by deriving statistical properties of model mechanisms and comparing these theoretical properties with experimental observations of asynchronous, proliferating cell cultures. As bits and pieces of the division-control mechanism are discovered by modern molecular and genetic techniques, the experience gained by the proposed theoretical approach will be valuable in putting together a complete picture of the regulatory system for cell growth and division. Since cell growth and division are fundamental processes in several areas of medical science (e.g., tumor growth, developmental disorders, and the spread of pathogenic microorganisms), basic research on the underlying regulatory mechanisms is vital to the interests of national health.