THE EPIDEMIOLOGY OF EARLY REPRODUCTIVE LOSS

总体目标是进一步阐明异常产前的原因。 通过研究已知核型的自然流产而取得的进展 和形态。风险因素将从对 收集了约2700名女性的广泛和系统的病史 染色体正常(整倍体)和染色体异常(非整倍体) 自然流产和4400名对照妇女在28周分娩 怀孕或晚些时候。这些数据是在12年的时间里收集的 纽约市的三家医院。 在整个收集期间，对这些数据的分析得出了一个 自发性整倍体和非整倍体决定因素的研究进展 堕胎。提出了进一步的分析，以复制和阐述一些 关联，以进一步探索不一致之处(随着时间的推移或与 社会人口学特征)在其他暴露的关联中 自然流产，并检查新的研究问题。这个 具体目的是：描述自发性整倍体的流行病学 堕胎，包括第一次努力系统地研究堕胎的风险因素 胎儿和非胎儿的损失；描述三体的流行病学；检查 恶心是否是妊娠生存能力的指标； 受孕、识别风险因素和寻求 与核型的关联；分析与DNA加合物形成相关的数据 在吸烟者的胎儿中；发展对早期的系统研究 (亚临床)妊娠丢失。

The overall goal is to elucidate further the causes of abnormal prenatal development through the study of spontaneous abortions of known karyotype and morphology. Risk factors will be derived from analyses of the extensive and systematic histories collected for about 2700 women with chromosomally normal (euploid) and chromosomally abnormal (aneuploid) spontaneous abortions and 4400 control women delivering at 28 weeks gestation or later. These data were collected over a twelve year period in three New York City hospitals. Analyses of these data, throughout the period of collection, have yielded a number of insights on determinants for euploid and aneuploid spontaneous abortion. Further analyses are proposed to replicate and elaborate some associations, to explore inconsistencies further (over time or with sociodemographic characteristics) in the associations of other exposures with spontaneous abortion, and to examine new research questions. The specific aims are to: describe the epidemiology of euploid spontaneous abortion, including a first effort to study systematically risk factors for fetal and non-fetal losses; describe the epidemiology of trisomy; examine whether nausea is an indicator of the viability of the pregnancy; for length of time to conception, to identify risk factors, and seek associations with karyotype; analyze data relating to DNA adduct formation in the fetuses of smokers; develop a systematic study of early (subclinical) pregnancy loss.