In-flow Preparation and use of Diazo Compounds for Heterocycle Construction

杂环化合物，其中一个或多个碳原子被氮、氧或硫取代的环结构非常重要。它们占所有已知有机化合物的一半以上，许多类别的天然产品以及绝大多数具有重要商业价值的药物、农用化学品和复制材料都含有杂环。因此，这类化合物的合成和研究无论在学术界还是工业界都是一个具有重大意义的课题。杂环化合物的商业相关性从畅销药品排行榜上得到了充分的证明--2006年，最畅销的十种药物中，有六种是氮杂环化合物，总销售额为410亿美元。这项提议得到了辉瑞的全力支持，旨在寻求支持，以重氮化合物的多种化学成分为基础，开发高效的流入杂环化合物的途径。

Heterocyclic compounds, ring structures in which one or more carbon atom is replaced by nitrogen, oxygen or sulfur are of vast importance. They account for well over half of all known organic compounds, and many classes of natural products, as well as a large majority of commercially important medicines, agrochemicals and reprographic materials, contain heterocyclic rings. Hence the synthesis and study of such compounds is a subject of immense significance, both in academia and industry. The commercial relevance of heterocyclic compounds is amply demonstrated by the list of best selling pharmaceuticals - for the year 2006, six of the top ten best sellers were nitrogen heterocycles with combined sales of $41 billion. This proposal, which has the full support of Pfizer, seeks support to develop efficient in-flow routes to heterocyclic compounds, based on the versatile chemistry of diazo compounds.