FAT METABOLISM AND EXPERIMENTAL ATHEROSCLEROSIS

这项建议的主要目的是阐明 实验性动脉粥样硬化中的含脂蛋白。 胆固醇从乳糜微粒和乳糜微粒残余物流入兔主动脉 将与低密度脂蛋白胆固醇进行比较。 的作用 将检查脂蛋白受体和内吞作用。 类似的研究， 还将在非人灵长类动物和细胞培养系统中进行研究。 的 将研究人血浆中胆固醇酯交换蛋白的性质 及其在胆固醇酯在脂蛋白之间转移中的作用， 其他和脂蛋白和细胞之间将被调查。 研究 超过脂肪条纹阶段的病变进展将通过结合 对动脉造成机械性损伤并改变饮食

The broad aims of this proposal are to elucidate the role of triglyceridecontaining lipoproteins in experimentally produced atheromatosis. Cholesterol influx from chylomicron and chylomicron remnants into rabbit aorta will be compared to that of low density lipoprotein cholesterol. The role of lipoprotein receptors and of endocytosis will be examined. Similar studies in subhuman primates and in cell culture systems will also be pursued. The properties of cholesteryl ester exchange protein in human plasma will be studied and its role in the transfer of cholesteryl ester between lipoproteins with each other and between lipoproteins and cells will be investigated. Studies on lesion progression beyond the fatty streak stage will be performed by combining mechanical injury to the artery with diet modifications.