Bar-Coded Biomaterials - Designing Self-Authenticating Medicines

新兴的个性化医疗领域需要结合创新的诊断学、治疗学和医疗点使用，以便为行业、临床医生和患者提供真正的优势。检测和抗击疾病的材料需要易于组装，达到其生物目标，并以精确可控的、针对患者或疾病的方式释放其信号/有效载荷。这项提议旨在开发一类新的生物材料，其中组装、释放和报告功能明确编码在其结构中。这些“条形码生物材料”将拥有分子“密码”，可以根据疾病和患者的需要定制释放信号和药物，也可以用来追踪和验证药物和携带者的体内命运。项目的成功完成将带来功能材料的新范式，对未来的医学和其他领域产生影响。

The emerging field of personalised medicine requires a combination of innovative diagnostics, therapeutics and 'point-of-care' use, in order to offer real advantages to industry, clinician and the patient. Materials for detecting and combating disease need be easily assembled, reach their biological targets and release their signals/payloads in precisely controllable and patient-or disease-specific ways. This proposal aims to develop a new class of biomaterial, where the assembly, release and reporting function is explicitly encoded in its structure. These 'Bar-Coded Biomaterials' will have molecular 'ciphers' that can be customised to release signals and drugs according to disease and patient need, and which can also be used to trace and validate the in vivo fate of the drug and carriers. Successful project completion will lead to a new paradigm in functional materials, with impact in future medicine and beyond.