NEUROTRANSMITTERS AND CENTRAL CONTROL OF BLOOD PRESSURE

孤束核（NTS）已被广泛研究， 关于它的生理功能和组织化学;然而， 已知这些功能与假定的 在NTS中识别的发射机。 了解这些关系可以 有助于理解某些生理功能是如何被调节的 并相互结合，可以揭示潜在的机制， 高血压的发生和控制血压 - 是的 这个项目的目标是确定 十种神经递质与六种生理功能的关系 （血压、心率、呼吸频率、皮层电活动， 胃运动和交感神经活动）。 将特别强调压力感受器反射和 确定L-谷氨酸在介导 反射。 预期每种假定的微注射的递质 进入NTS将引起不同的生理反应， 各自的拮抗剂会阻断这些反应。 那些安格利亚主义者 其在其生理概况中产生血压的变化， 将进一步研究心率，以确定它们与 压力感受器反射 这些假定的发射器是 压力感受器反射将通过其拮抗剂的能力来识别 阻断反射并产生神经性高血压， 中枢压力感受器反射中断的急性结果，或 外围的 为释放相关药物提供生理学证据 来自压力感受器传入（或其他迷走神经传入）的递质， 对激动剂注射的超敏性将通过以下方法来寻求： 研究他们的剂量反应后，间隔单侧删除， 结状神经节 由于工作的一个主要重点将是中央 NTS中血压的控制，对 在心血管调节中有活性的激动剂（如上所述）将被 在一种形式的自发性高血压中， 高血压大鼠

The nucleus tractus solitarius (NTS) has been extensively studied with respect to its physiologic functions and histochemistry; yet little is known of the relationship between those functions and the putative transmitters identified in the NTS. Knowledge of such relationships could aid in understanding how some of those physiologic functions are mediated and integrated with each other and could reveal potential mechanisms for the genesis of hypertension and for controlling blood pressure pharmacologically. The goal of this project, then, will be to determine relatioships between ten neurotransmitters and six physiologic functions (blood pressure, heart rate, respiratory rate, electrocortical activity, gastric motility, and sympathetic nerve activity) modulated by the NTS. Particular emphasis will be placed on the baroreceptor reflex and on establishing the integral role played by L-glutamate in mediating that reflex. It is anticipated that each putative transmitter microinjected into the NTS will elicit a distinct profile of physiologic responses and that respective antagonists will block those responses. Those angonists which produce, in their physiologic profile, changes in blood pressure and heart rate will be further studied to determine their relationship to the baroreceptor reflex. Those putative transmitters integral to the baroreceptor reflex will be identified by the ability of their antagonists to block the reflex and to produce neurogenic hypertension, an invariable acute result of interruption of the baroreceptor reflex centrally or peripherally. To provide physiologic evidence for release of the relevant transmitters from baroreceptor afferents (or other vagal afferents), supersensitivity to the injection of the agonists will be sought by studying their dose responses at intervals after the unilateral removal of the nodose ganglion. Since a major focus of the work will be the central control of blood pressure in the NTS, changes in the sensitivity to agonists active in cardiovascular regulation (as identified above) will be sought in one form of spontaneous hypertension, the spontaneously hypertensive rat.