Signal Amplification in NMR and MRI using hyperpolarised compounds

核磁共振中心和约克大学的神经成像中心开展了一项工作计划，证明传统核磁共振和核磁共振成像技术的一个基本限制可以显著克服。核磁共振是进行分析和结构化学的最流行的方法，核磁共振是在人体内进行非侵入性成像的首选技术。尽管正如美国最近提交给国会的一份报告所指出的那样，这些技术的全球市场每年超过60亿美元，但由于敏感度较低，这两种技术的应用都受到限制。在过去的十年里，约克郡发展了一种被称为超极化的过程，可以克服这些限制。我们最近已经证明，在传统设备上，0.5秒的数据收集相当于58天。在外行的术语中，核磁共振和核磁共振都涉及分子内原子核的磁性行为的探测。这些原子核的行为就像条形磁铁，因此可以有北向或南向的取向。仲氢只是一种反应原料，我们从纯磁性形式开始，而不是具有这样的取向的混合物。我们已经建立了一条在MR研究中利用这种原料的新途径。副氢的作用就像一个散热器，当它与周围环境接触时，就会使房间变得温暖。在这种情况下，结果是检测到的信号强度可能增加31,000。通过和平研究所研究获得的信息被公认为提供了与卫生领域的诊断和治疗有关的关键信息。灵敏度增强方面的突破为现代医疗保健和高分辨率核磁共振市场提供了阶段性变化的机会。这是在不需要对材料进行化学修饰的情况下实现的，它可以使用人体固有的物质。因此，我们预计它将不会受到与Gd造影剂和PET相关的毒理问题的困扰，因此受到医学界和非专业人士的欢迎。详情请参阅建议书

The NMR Centre and the Neuroimaging Centre at the University of York have conducted a programme of work that has demonstrated that one of the fundamental limitations of conventional Nuclear Magnetic Resonance (NMR) and Magnetic Resonance Imaging (MRI) techniques can be dramatically overcome. NMR is the most popular method for performing analytical and structural chemistry and MRI is the technique of choice for carrying out non-invasive imaging in humans. Even though the global markets for these techniques exceeds 6billion annually, as identified in a recent US report to Congress, both technologies are limited in application due to poor sensitivity. A process termed hyperpolarisation, developed in York throughout the last decade, allows these limitations to be overcome. We have recently shown that 0.5 seconds worth of data collection equates to 58 days on the conventional device.In laymen's terms, both NMR and MRI deal with the probing of the magnetic behaviour of nuclei within molecules. These nuclei behave like bar magnets and therefore can either have a north or south seeking orientation. Parahydrogen is simply a reaction feedstock where rather than having a mixture of such orientations, we start with a pure magnetic form. We have established a new route to utilising this feedstock in MR studies. The parahydrogen simply acts like a radiator which when brought into contact with its surroundings warms the room. In this case, the result is a potential 31,000 increase in detected signal strength. The information obtained through MIR studies is well established as providing critical information related to diagnosis and treatment in the health field. The breakthrough in sensitivity enhancement offers opportunities for a step change in modern healthcare and in high resolution NMR markets. This is achieved without the chemical modification of a material and it can employ substances that are native to the body. We therefore expect that it will not suffer from the toxicological problems associated with gadolinium contrast agents and PET and hence be well received by the medical community and laymen alike.Please see Proposal Form for details