Molecular basis of synergy between PIs and defensins against fungi

植物防御素烟酰胺腺嘌呤二核苷酸脱氢酶亚基1（NaD 1）对农业和人类病原菌具有有效的抗真菌活性，并且在治疗影响作物生产和人类健康的严重疾病方面具有潜力。已发现NaD1使膜透化，并允许其他分子进入真菌细胞质。在筛选增强防御素活性的分子时，鉴定了许多与NaD1协同作用的蛋白酶抑制剂。该项目旨在确定这种协同作用的分子基础，预计将导致更好地控制作物和人类的真菌疾病。

The plant defensin nicotinamide adenine dinucleotide dehydrogenase subunit 1 (NaD1) has potent antifungal activity against agricultural and human pathogens and has potential in the treatment of serious diseases that affect crop production and human health. NaD1 has been found to permeabilise membranes and allows entry of other molecules into the fungal cytoplasm. While screening for molecules that enhance the activity of defensins a number of proteinase inhibitors were identified that act synergistically with NaD1. This project aims to identify the molecular basis of this synergy which is expected to lead to better control of fungal diseases of crops and in humans.