Decision-making modules in protein interaction networks

该项目旨在发现细胞如何利用蛋白质来做出决定。这对所有生物都很重要，它们必须对刺激做出反应，才能生长、适应、自卫和死亡。该项目的预期结果是对蜂窝内网络中的决策模块进行系统级识别。它的重点是尽可能小的模块，其中包含一个带有两个修饰的决策蛋白质，这些修饰控制着蛋白质之间的相互作用。它将调查两个经常性的决策模块。该项目的预期收益包括破译生物复杂性的新方法，以及通过基因组编辑或药物调节生物系统的目标。

This project aims to discover how cells use proteins to make decisions. This is important for all living things, which must react to stimuli to grow, adapt, defend themselves and to die. The project’s anticipated outcome is the systems-level identification of decision-making modules in an intracellular network. Its focus is on the smallest possible modules, which contain a decision-making protein with two modifications that control protein-proteins interactions. It will investigate two recurrent decision-making modules. The expected benefits of the project include new means to decipher biological complexity, and targets to modulate biosystems by genome editing or with drugs.