E-TERM, Engineering Tissue Engineering and Regenerative Medicine

国民健康状况的持续改善取决于有效开发负担得起的替代人体组织和相关疗法；自愿器官捐献者的严重短缺和传统治疗方法的缺陷导致每年许多患者本可预防的死亡。下一次医疗保健革命将应用再生医学，创造生物疗法或替代品，以替代或恢复因失败或疾病而丧失的组织功能。然而，虽然科学已经揭示了这种疗法的潜力，并且早期的产品已经显示出这种疗法的力量，但现在需要长期供应经过适当培训并具备必要技能的人员，以便在人类医疗保健的预期益处得以实现之前，领导工程和生命科学挑战。实现这些好处需要新一代的翻译专业领导者，他们既沉浸在这些新产品的基础科学中，也沉浸在其创造和应用的临床、工程和商业现实中。该提案首次将六个大学团队和相关的年轻研究人员聚集在一起，这些研究人员参与了由EPSRC生命科学接口计划资助的两个再生医学dtc。每个大学小组都在各自的领域独立地处于国际领先地位，并从EPSRC生命科学接口计划和其他地方吸引了大量资金。拟议的景观奖提供了一个机会，将六个小组的研究优势结合起来，提供一个跨学科研究的战略合作计划，并培养一批组织工程和再生医学领域的未来研究领导者。拟议的研究计划是真正的跨学科，需要从基础细胞生物学到生物工程、生物力学和组织工程，再到生物加工、监管制造和商业化的专业知识。

Continued improvement in the nation's health depends upon the efficient development of affordable replacement human tissue and related therapies; an acute shortage of willing organ donors and the shortcomings of conventional therapies leads to the preventable death of many patients each year. The next healthcare revolution will apply regenerative medicines, creating biological therapies or substitutes for the replacement or restoration of tissue function lost through failure or disease. However, whilst science has revealed the potential, and early products have shown the power of such therapies, there is now a need for the long term supply of people properly trained with the necessary skills to lead the engineering and life science challenges before the predicted benefits in human healthcare can be realised. Realisation of these benefits requires a new generation of translational professional leaders immersed in both the fundamental science of these new products and the clinical, engineering and commercial realities of their creation and application.This proposal brings together for the first time the six University teams, and the associated growing cohorts of young researchers, involved in the two Regenerative Medicine DTCs funded through the EPSRC Life Sciences Interface Programme. Each University group is independently internationally leading in their field, and has attracted significant funding from the EPSRC Life Sciences Interface Programme and elsewhere. The proposed Landscape Award offers the opportunity to combine the research strengths of the six groups to deliver a strategic collaborative programme of cross-disciplinary research, and a cohort of future research leaders in tissue engineering and regenerative medicine. The proposed research programme is truly cross-disciplinary, requiring expertise that ranges from fundamental cell biology, through biological engineering, biomechanics and tissue engineering, to bioprocessing, regulated manufacturing, and commercialisation.