NEURAL CORRELATES OF VOCAL LEARNING

使用3 H-胸苷的放射自显影研究表明， 添加到成年金丝雀的腹侧上纹状体，尾侧部（HVc） 个脑袋 HVc位于前脑，是歌曲控制系统的一部分， 歌曲学习 新的神经元由心室肌细胞分裂形成 区域细胞，然后迁移，分化并连接到现有的 电路 未来5年的研究计划将描述 在这个系统中神经元募集的动力学， 它，以及新神经元取代旧神经元的可能性。 3 H-胸苷和放射自显影将继续用于这项工作，因为 以及类固醇激素的硅橡胶植入物， 耳蜗和红藻氨酸损伤。 神经发生的意义和 成人HVc中的神经元替代将通过寻找时间来研究。 这些现象之间的相关性和一年中成年人 金丝雀特别容易学习新的歌曲音节，忘记旧的。 一个 这里检验的假设是， 歌曲学习、歌曲遗忘和替代的时间发生 HVc神经元 行为研究将包括歌曲录音， 声谱分析 在这种情况下，我们的具体目标将 be：1.为了测量歌曲知觉和运动记忆的半衰期， 成年雄性金丝雀，以及它们对激素依赖的程度。 2.为了确定神经发生和神经元的季节性发生， 成年金丝雀的更替，以及它们与 歌曲不稳定，遗忘和学习。 3.为了确定在多大程度上， 如果有的话，激素和经验会影响神经发生和神经元 更换HVC。 4.确定新HVc的生存曲线 神经元，以及它们在不同神经元之间可能变化的程度 班 5.为了确定新的HVc神经元在迁移过程中如何定向， 找个地方工作 6.为了确定神经元募集到什么程度 发生在从孵化到性成熟的时期， 招聘（和替换？）在那个时候发生的事情， 发生在成年期。 7.干扰神经元 在成人HVc中的招募和神经元替代，以了解这如何影响 记忆保持和学习新歌。 神经发生的发生和意义的认识， 成年人大脑中的神经元替代可能会对 神经学实践

Autoradiographic studies using 3H-thymidine indicate that new neurons are added to hyperstriatum ventralis, pars caudalis (HVc) of the adult canary brain. HVc is in the forebrain and is part of the song control system used in song learning. The new neurons are formed by division of ventricular zone cells, then migrate, differentiate and become connected to existing circuitry. Research planned for the next 5 years will describe the dynamics of neuronal recruitment in this system, the factors that control it, and the possibility that the new neurons replace older neurons. 3H-thymidine and autoradiography will continue to be used for this work, as well as silastic implants of steroid hormones, deafening by removal of both cochleas, and kainic acid lesions. The significance of neurogenesis and neuronal replacement in adult HVc will be studied by searching for temporal correlations between these phenomena and times of year during which adult canaries are particularly prone to learn new song syllables and forget old ones. The hypothesis tested here is that there is a correlation between the temporal occurrence of song learning, song forgetting and replacement of HVc neurons. The behavioral studies will involve song recording and sound-spectrographic analysis. Within this scenario our specific aims will be: 1. To measure the half-life of song perceptual and motor memories in adult male canaries, and the extent to which they are hormone dependent. 2. To determine the seasonal occurrence of neurogenesis and neuronal replacement in adult canaries, and their temporal relation to periods of song instability, forgetting and learning. 3. To determine to what extent, if any, hormones and experience influence neurogenesis and neuronal replacement in HVc. 4. To determine the survival curves of new HVc neurons, and the extent to which they may vary between different neuronal classes. 5. To determine how new HVc neurons orient during migration and find a place to work. 6. To determine to what extent neuronal recruitment occurs during the period from hatching to sexual maturity, so that patterns of recruitment (and replacement?) occurring at that time can be compared with those occurring in adulthood. 7. To interfere with neuronal recruitment and neuronal replacement in adult HVc to see how this affects memory retention and learning of new songs. An appreciaton of the occurrence and significance of neurogenesis and neuronal replacement in adult brain could have profound effects on neurological practice.