HYPERKINETIC BOYS AND THEIR SIBLINGS AS YOUNG ADULTS

这是一项对患有自闭症的男孩进行的成人随访研究的最后阶段。 多动症/注意力缺乏症， 非多动的全兄弟，以及他们的非多动的前 同学 所有患者最初在4至12岁时被转诊至 爱荷华州大学儿童精神病学门诊。 样品 包括：（a）早期用药组（1967-1972年期间转诊， 哌醋甲酯）; B）过渡药物组（在 1972-1975年，主要用哌醋甲酯治疗）; c）过渡性 未用药组（也在1972-1975年之间提及，UT，因为 医生偏好，不使用精神药物治疗）;和d）a 晚期未用药组（1976-1978年期间转诊，未接受 精神药物）。 这些研究的总体目的是（a）描述成人结局 并将其与亲生兄弟的结果进行比较， 同学控制;及（B）识别那些受试者及环境 预测结果差异的特征。 计划 比较将测试这些变量对结果的影响， 多动和攻击性;兴奋剂药物治疗;反应 药物;和物质使用/滥用。 制定方法， 预测和诊断残留ADD/成人MBD将是一个特殊的 关心 1988年和1989年，对155例早期服药的老年人进行了21 ~ 23岁的随访， 先证者和66个兄弟完成。 此外，大多数 过渡期组和晚期组（先证者72例，兄弟24例， 同学）也在21至23岁完成了评估。 最后， 早期用药组的71名先证者和他们的31名兄弟， 在28到32岁之间进行评估。 在拟议的两年赠款期内，数据 并会对二十一至二十三岁的样本进行分析。 分析 适合28至32岁的部分样本 主题和兄弟也将进行。

This is the final phase of an adult follow-up study of boys with Hyperkinetic/Attention Deficit Disorder (HK/ADD), of their nonhyperkinetic full brothers, and of their nonhyperkinetic former classmates. All patients were originally referred at ages 4 to 12 to the University of Iowa child psychiatry outpatient clinic. The samples include: a) an Early Medicated group (referred between 1967-1972 and methylphenidate); b) a Transitional Medicated group (referred between 1972-1975 and treated primarily with methylphenidate); c) a Transitional Unmedicated group (also referred between 1972-1975,ut, because of physician preference, not treated with psychotropic drugs); and d) a Late Unmedicated group (referred between 1976-1978 and not treated with psychotropic drugs). The general aim of these studies is to (a) describe the adult outcomes of HK/ADD and compare them with the outcome of biological brothers and classmate controls; and (b) to identify those subject and environmental characteristics that predict differences in outcome. Planned comparisons will test the effects on outcome of such variables as hyperactivity and aggression; stimulant drug treatment; response to medication; and substance use/abuse. Establishing methods for predicting and diagnosing residual ADD/adult MBD will be a special concern. In 1988 and 1989, the 21-to-23-year-old follow-up of 155 Early Medicated probands and 66 brothers was completed. In addition, the majority of the Transitional and Late groups (72 probands, 24 brothers, and 51 classmates) also completed their evaluations at ages 21 to 23. Finally, 71 probands in the Early Medicated group an 31 of their brothers were evaluated at ages 28 to 32. In the proposed two-year grant period, data analysis for the 21 to 23 year old samples will be conducted. Analyses that are appropriate for the partial sample of 28 to 32 year old subjects and brothers will also be conducted.