ANXIETY AND REGIONAL CEREBRAL BLOOD FLOW

这项研究的目的是评估两者之间的联系 局部脑血流量(RCBF)和焦虑。地区性 将在静息状态下测量脑血流量和 焦虑症患者的急性焦虑期间和 与正常对照组相匹配。133Xe吸入技术将被 用于测量脑毛细血管的血流灌注量。 脑血流测量中的焦虑程度 将通过评级量表和外周生理指标进行量化 指数。一些与焦虑相关的变量，如红细胞压积， 纤维蛋白原、血红蛋白和二氧化碳 牵涉到对脑血流的控制将受到监测。 患者和对照组都会通过一种 静脉滴注0.2微克/公斤/毫升肾上腺素或 生理盐水在双盲条件下给药。 这个项目可能会识别与焦虑相关的大脑区域。 这些信息对类似的研究将具有相当大的价值。 其他精神疾病的项目，因为焦虑是一种 是大多数精神疾病的组成部分。它还将检查 CBF作为焦虑的客观指标的可能性。这个 这一研究结果可能有助于神经化学的研究。 精神障碍。这也解释了中央银行 脑缺血的机制，通常与 急性焦虑症。最后，它可能会提供对 焦虑、二尖瓣脱垂与中风的关系。

The aim of the study is to evaluate the association between regional cerebral blood flow (rCBF) and anxiety. Regional cerebral blood flow will be measured under resting conditions and during acute anxiety in patients with anxiety disorders and matched normal controls. 133Xenon inhalation technique will be utilized for measurement of the brain capillary perfusion. Degrees of anxiety during the cerebral blood flow measurement will be quantified via rating scales and peripheral physiological indices. Several anxiety related variables such as hematocrit, fibrinogen, hemoglobin and carbon dioxide which have been implicated in the control of cerebral blood flow will be monitored. Anxiety will be induced in both patients and controls via an intravenous infusion of .2 microgram/Kg/mt of epinephrine or normal saline given under double-blind conditions. This project might identify the brain regions related to anxiety. This information will be of considerable value to similar research projects on other psychiatric illnesses since anxiety is a component of most psychiatric conditions. It will also examine the possible use of CBF as an objective index of anxiety. The result of the study may facilitate neurochemistry research on psychiatric disorders. It would also explain the central mechanisms of cerebral ischemia, commonly associated with acute anxiety. Lastly, it might provide new insights into the association between anxiety, mitral valve prolapse and stroke.