DNA MARKER STUDY OF LINKAGE TO SCHIZOPHRENIA IN CROATIA

拟议的项目将使用精神病登记册和其他数据 社会主义共和国公共卫生研究所的资源 克罗地亚将在南联盟建立一个高密度的家庭数据库 家系，受影响的同胞对，和其他对，受影响的亲属与 精神分裂症的目的进行DNA标记连锁研究。 在 本申请初步为期三年，我们建议（1） 筛选精神病登记册和支持文件，以确定 精神分裂症先证者与受影响的家庭成员，并建立 在个人电脑上建立家庭数据库，（2）培训共同调查员， 其他临床医生谁将进行诊断访谈，在使用 根据DSM-IIIR和RD C进行结构化访谈和评级。（三） 进行诊断面谈，并收集血液样本， 大约490人（精神分裂症先证者及其亲属）， (4)开始对血液样本进行分子遗传学分析 纽约州立精神病医院医学遗传学系实验室 研究所，永生细胞系，并开始DNA标记物的测定 （候选基因、5号染色体探针等），（5）开始于 根据几种方法中的任何一种进行初步连锁分析， 适合于已确定的家庭结构。

The proposed project will use the Psychoses Register and other data resources at the institute of Public Health of the Socialist Republic of Croatia in Yugoslavia to establish a family data bank with high-density pedigrees, affected sib-pairs, and other pairs, of affected relatives with schizophrenia for the purpose of conducting DNA marker linkage studies. In this application for an initial three-year period, we are proposing (1) to screen the Psychoses Register and supporting files to identify schizophrenic probands with affected family members and to establish the family data bank on a PC, (2) to train the Yugoslavian Co-investigators and other clinicians who will be conducting diagnostic interviews in the use of structured interviews and ratings according to DSM-IIIR and the RD C. (3) to conduct diagnostic interviews and collect blood samples from approximately 490 individuals (schizophrenic probands and their relatives), (4) to begin work-up of the blood samples in the Molecular Genetics Laboratory, Department of Medical Genetics, New York State Psychiatric institute, immortalize cell lines, and begin the assay of DNA markers (candidate genes, chromosome 5 probes, etc.), and (5) to begin in preliminary linkage analyses according to any of several methods, as appropriate to the family structures that are identified.