Lattice light sheet microscopy for imaging biology in real space and time

该项目旨在建立一个晶格光片显微镜(LLSM)设施，以提供TB级图像采集和处理所需的专用计算基础设施。晶格光片显微镜可以对从单个分子到小型生物体的活体生物标本进行四维成像。该显微镜对活体标本进行成像，没有光毒性或光漂白，能够对重要的生理或生物物理事件进行长时间成像。预期成果包括基础研究的高影响力发现和出版物、以行业为重点的项目的快速解决方案以及合作、研究和开发的机会。预计成像将揭示关键的科学见解，并向公众展示生物学。

This project aims to establish a Lattice Light-Sheet Microscope (LLSM) Facility, to provide the dedicated computing infrastructure needed for terabyte-scale image acquisition and handling. Lattice light sheet microscopy allows four-dimensional imaging of live biological specimens from individual molecules to small organisms. The microscope images live specimens without phototoxicity or photobleaching, enabling prolonged imaging of significant physiological or biophysical events. Expected outcomes include high impact discoveries and publications in fundamental research, rapid solutions for industry-focussed projects and opportunities for collaboration, research and development. The imaging is expected to reveal key scientific insights and showcase biology to the public.