Advanced lattice light sheet microscope optimised for biological imaging

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This project provides a lattice light sheet microscope optimised for biological applications and user utility. Lattice light sheet microscopy combines optical, physical and technical attributes that achieve high spatio-temporal resolution imaging of biological specimens for long periods with minimal phototoxicity, making practical for the first time high-resolution longitudinal volumetric analyses of living specimens. It is suitable for imaging cultured cells, organoids, small embryos, and small model organisms such as zebrafish larvae at cellular and subcellular resolution. Expected outcomes are high impact discoveries, training opportunities, international collaborations and publications addressing fundamental questions in biology.