NEURODEVELOPMENTAL & SOCIOEMOTIONAL ANTECEDENTS OF SCHIZ

本提案中描述的研究涉及识别 精神分裂症的发展前兆和检查 发育因素与神经心理学和神经解剖学之间的联系 精神分裂症的特征 该研究使用的方法是 最好的描述是一个档案，观察的方法;童年的家- 电影将作为神经运动和社会情感的主要数据库， 发展的各个方面，从婴儿期开始， 青春期 受试者是在1999年死于精神分裂症的个体。 青春期晚期/成年早期。 将有三个对照组; 被诊断为情感障碍的患者，患者的健康兄弟姐妹， 以及来自没有精神疾病的核心家庭的受试者。 除了 儿童时期的家庭电影，广泛的发展和家族史数据， 收集所有科目。 患者及其同胞对照组将 还接受神经心理学评估和磁共振成像 (MRI)扫描大脑。 以前颁发的赠款将涵盖 收集档案数据和评估受试者。 这项建议 要求提供资金，以支付进行广泛观察的人员费用， 分析录像带，组织、储存和分析数据。 的 该项目的主要目标是：1）绘制发展轨迹 导致精神分裂症，2 @确定潜在的关系 病因（围产期并发症和精神分裂症家族史） 疾病）和发展特征，以及3）检查关系 病因因素、发育特征和 神经心理学和神经解剖学方面的主题作为成人。 因为研究的方法将允许直接微观层面 通过对儿童时期行为的分析， 对前中世纪的发展有了更广泛的认识， 可能与以前的方法。

The research described in this proposal is concerned with identifying developmental precursors of schizophrenia and examining the relation between developmental factors and neuropsychological and neuroanatomical characteristics of schizophrenia. The research uses a methodology that is best described as an archival, observational approach; childhood home- movies will serve as the primary data-base on neuromotor and socioemotional aspects of development, beginning in infancy and extending through early adolescence. Subjects are individuals who succumbed to schizophrenia in late adolescence/early adulthood. There will be three comparison groups; patients diagnosed with affective disorder, healthy siblings of patients, and subjects from nuclear families with no mental illness. In addition to the childhood home-movies, extensive developmental and family history data are collected on all subjects. Patients and their sibling controls will also receive a neuropsychological assessment and magnetic resonance image (MRI) scan of the brain. Previously awarded grants will cover the collection of archival data and assessments of subjects. This proposal requests funds to cover the costs of personnel for extensive observational analyses of videotapes and organization, storage and analyses of data. The chief goals of the project are to: 1) chart the development trajectories leading to schizophrenia, 2@determine the relation between potential etiologic factors (perinatal complications and family history of mental illness) and developmental characteristics, and 3) examine the relations among etiologic factors, developmental characteristics, and neuropsychological and neuroanatomical aspects of the subjects as adults. Because the methodology of the study will allow for direct microlevel analyses of behavior across the childhood years, it holds promise for yielding a broader view of preschizophrenic development than has been possible with previous approaches.