MECHANISMS OF CENTRAL PATTERN GENERATION IN GANGLIA

节律运动模式的神经连接和机制是 目前未知。 为了理解这些机制， 在无脊椎动物模型系统中，可以使用龙虾胃神经节 来研究节奏运动模式的起源 这个只有30人的神经节 细胞产生两个独立的节奏，在隔离和完全去传入 准备. 这两种模式背后的神经回路 测定 使用一种新的染料敏化光灭活技术， 已经阐明了幽门节律产生的机制。 本提案旨在使用 同样的实验技术，但以更定量的方式。 我们有 提出了一个胃机制的初步假设， 来预测特定细胞缺失的后果。 这些将是 经过实验检验，并根据需要修改假设。 此外 我们将开始检查胃肠道的感觉控制 模式的产生和神经调节物质的作用 眼柄中的神经抑制激素;血清素和章鱼胺， 存在于胃肠道系统中。

The neural connections and mechanisms underlying rhythmic motor patterns is at present not known. In an effort to understand these mechanisms, and invertebrate model system, the lobster stomatogastric ganglion can be used to study the genesis of rhythmic motor patterns. This ganglion of only 30 cells produces two separate rhythms in isolated and completely deafferented preparation. THe neural circuitry underlying both patterns has been determined. Using a new dye-sensitized photoinactivation technique, the mechanisms for the production of the pyloric rhythm have been elucidated. This proposal is to complete an analysis of the gastric system using the same experimental technique, but in a more quantitative manner. We have formulated a tentative hypothesis for the gastric mechanism which allows us to predict the consequences of particular cell deletions. These will be experimentally tested and the hypothesis modified as required. In addition we will begin an examination of the sensory control of the stomatogastric pattern generation and the effects of the neuromodulatory substances neurodepressing hormone from the eyestalk; serotonin and octopamine, which are found in the stomatogastric system.