CELLULAR NEURONAL CONTROL OF BEHAVIOR

这个项目的长期目标是描述细胞机制。 以及作为控制媒介的神经网络的组织原则 关于行为的。它集中在腹神经节中的神经元。 控制呼吸、循环系统和肾脏系统的加州海兔 在这种腹足软体动物中。在即将到来的赠款期间，神经 对呼吸泵的控制，一种全有或非全有的刻板印象行为，即 由28个触发单元组成的网络中的刻板脉冲驱动，将是 学习。本项目将研究此行为的功能，即 产生它的机制，以及产生它的机制 调制过的。关于这一行为的五个具体假设是 测试： (1)不同的呼吸泵模式服务于不同的自主神经 功能。一种模式增强呼吸系统对氧气的吸收 另一种则能增强肾功能。 (2)R15和R20细胞，两种类型的肽能调制神经元 增加呼吸泵频率，确定呼吸泵模式 在体外，它们在体内不同的生理条件下都很活跃。 (3)R25/L25网络爆发了人口的陈规定型观念阶段， 它为行为的强模式提供了要么全有要么全不的功能，是一个 R25/L25细胞间突触联系的突发性 网络。 (4)通过以下方式在其强模式和弱模式之间切换行为 脑内细胞间突触联系的异突触调制 R25/L25网络。 (5)R25/L25网络对R15中的活动的响应持续时间 主要由R15‘S突触作用的脱敏所决定。这 脱敏作用可被其他突触调节。 这些拟议的呼吸泵研究将提供更好的 了解以下内容： (1)固定行为背后的神经机制。 (2)复杂刻板印象行为背后的神经机制。 (3)肽能神经元对中枢模式发生器的调制。 (4)内源性爆裂细胞的生理功能。 (5)脱敏的功能作用。 (6)自主神经功能的神经元整合。 (7)软体动物自主神经功能。

The long term goal of this project is to describe the cellular mechanisms and principles of organization of neural networks that mediate the control of behavior. It is focussed on the neurons in the abdominal ganglion of Aplysia california that control respiratory, circulatory and renal systems in this gastropod mollusc. During the coming grant period, the neural control of respiratory pumping, an all-or-non, stereotyped behavior that is driven by a stereotyped burst in a network of 28 trigger cells, will be studied. This project will examine the function of this behavior, the mechanisms by which it is generated, and the mechanisms by which it is modulated. Five specific hypotheses concerning this behavior will be tested: (1) Different patterns of respiratory pumping serve different autonomic functions. One pattern enhances the uptake of O2 by the respiratory system of the animal, while the other enhances renal function. (2) R15 and the R20 cells, 2 types of peptidergic modulatory neurons that increase the frequency and determine the mode of respiratory pumping in vitro, are active under different physiological conditions in vivo. (3) The stereotypes phase of the population burst in the R25/L25 network, which gives the strong mode of the behavior its all-or-none feature, is an emergent property of the synaptic connections between cells in the R25/L25 network. (4) The behavior is switched between its strong and weak modes by heterosynaptic modulation of the synaptic connections between cells in the R25/L25 network. (5) The duration of the response of the R25/L25 network to activity in R15 is determined primarily by desensitization of R15's synaptic action. This desensitization can be modulated by other synaptic. These proposed studies of respiratory pumping will provide a better understanding of: (1) The neural mechanisms that underlie fixed acts. (2) The neural mechanisms that underlie complex stereotyped behaviors. (3) The modulation of central pattern generators by peptidergic neurons. (4) The physiological function of endogenous bursting cells. (5) The functional role of desensitization. (6) The neuronal integration of autonomic function. (7) Molluscan autonomic function.