OSTEOGENIC POTENTIAL OF DBP AND HYDROXYLAPATITE

颗粒羟基磷灰石（HA）已被用于增加下颌骨和 自4月以来，美国有超过12,000名患者接受了上颌萎缩嵴治疗， 1982. 在这些高嵌体情况下，HA颗粒的质量保持在适当位置 致密纤维组织的形成 然而，显著的骨 只有当HA与 自体松质骨 骨长入HA脊是 被认为可以增加牙槽嵴的稳定性和下颌骨的力量。 不幸的是，获取自体移植物会增加疼痛，移动性， 医院费用。 脱矿骨粉（DBP）诱导成骨。 本研究将评估整个过程中诱导成骨的程度。 DBP与HA联合使用时HA增强牙槽嵴。 本研究将使用从尸体犬长骨中生产的DBP。 的in 在狗颈部皮下组织中的体内测定将证实 成骨诱导能力。 HA和 将DBP以1：1的体积比放置在骨膜下隧道中， 下颌骨嵴的狗，并保持在适当的位置， 预制夹板 对照材料将包括HA与 自体骨和单独DBP。 处死期将提供4， 隆乳后12、16和52周比较。 垂直高度 稳定性将通过使用标准 加工条件 骨形成将通过 土霉素荧光和组织学检查将检查 细胞细节。 灰分含量将量化矿化量 对于每个样本。

Particulate hydroxylapatite (HA) has been used to augment mandibular and maxillary atrophic ridges for over 12,000 patients in the U.S. since April, 1982. In these onlay situations the mass of HA particles is held in place by the development of dense fibrous tissue. However, significant bony ingrowth into the HA ridge is seen only when the HA is combined with autogenous cancellous bone. The ingrowth of bone into the HA ridge is thought to increase ridge stability and mandibular strength. Unfortunately, harvesting an autograft increases pain, mobidity, and hospital expense. Demineralized bone powder (DBP) induces osteogenesis. This study will evaluate the degree of induced osteogenesis throughout the HA-augmented ridge when DBP is combined with HA. DBP produced from cadaver dog long bones will be used in this study. An in vivo assay in the subcutaneous tissues in the dog's neck will confirm osteogenic induction ability for each batch of the synthesized DBP. HA and DBP in a 1:1 volume ratio will be placed in a subperiosteal tunnel on the mandibular ridge of the dogs and maintained in position by using prefabricated splints. Control materials will include HA combined with autogenous bone, and DBP alone. Sacrifice periods will provide data for 4, 12, 16, and 52 week post-augmentation comparisions. Vertical height stability will be followed by radiographic measurements using standard processing conditions. Bone formation will be identified by oxytetracycline fluorescence and histological examination will examine cellular detail. Ash content will quantitate the amount of mineralization for each specimen.