STRUCTURE AND CONNECTIONS OF RED NUCLEUS

这项建议的目的是了解结构和 大鼠红核的连通性。这项研究将构成基础 随后将进行一项功能研究。这其中的两个新发现 实验室表明，红宝石的脊髓和橄榄石的产量 是了解大鼠红核的良好模型系统 解剖组织原理和运动原理 控制和补偿。 第一个发现是红髓起源的神经元 束也投射到延髓的下橄榄核。 (初步数据部分和肯尼迪1987A)。这是使用以下工具显示的 红核神经元的双重标记。这些发现还包括 确认本实验室之前的预测报告 从红核到下橄榄核(见 附录A)。 第二个发现是红核到黑质的投射 下橄榄核参与病变的代偿 红核脊髓束。训练有素的老鼠不能恢复，或者只能 非常缓慢地，在红核损伤摧毁脑神经元后 红宝石-橄榄和红宝石-脊椎输出的起源。此外， 红宝石-橄榄油输出系统在持续控制中没有作用 运动测试是因为，如果老鼠已经补偿了 红椎脊髓束病变，其表现为最轻微且仅 在随后的红核病变后暂时受到影响。 这里提出的对这一系统的完整解剖描述 使用多种示踪剂将为功能研究提供指南 以及他们随后的解释。最终，这是意料之中的 理解红核的基本性质， 尤其是它在弥补神经缺陷方面的作用， 将为此类疾病的治疗方式提供合理的基础 中风和学习障碍等障碍。

The aim of this proposal is to understand the structure and connectivity of rat red nucleus. This study will form the basis of a functional study to follow later. Two new findings from this laboratory suggest that the rubro-spinal and rubro-olivary outputs of rat red nucleus are excellent model systems for understanding principles of anatomic organization as well as principles of motor control and compensation. The first finding is that neurons of origin of the rubrospinal tract also project to the inferior olivary nucleus in the medulla (Preliminary Data section and Kennedy 1987a). This was shown using double labelling of the red nucleus neurons. These findings also confirm the previous report from this laboratory of a projection from the red nucleus to the inferior olivary nucleus (paper in Appendix A). The second finding is that the projection from red nucleus to the inferior olivary nucleus is involved in compensation for lesions of the rubrospinal tract. Trained rats could not recover, or only very slowly, after red nucleus lesions destroy the neurons of origin of rubro-olivary and rubro-spinal outputs. In addition, the rubro-olivary output system plays no role in on-going control of movements as tested because, if the rat had already compensated for a rubrospinal tract lesion, its performance was minimally and only temporarily affected after a subsequent red nucleus lesion. The complete anatomical description of this system as proposed here using multiple tracers will provide a guide to functional studies and their subsequent interpretation. Ultimately, it is expected that understanding the fundamental nature of the red nucleus and, in particular, its role in compensation for neurological deficits, will lead to a rational basis for treatment modalities for such disorders as stroke and learning disabilities.