FUNCTIONAL ANALYSIS OF CEREBELLAR INTERPOSITUS NUCLEUS

这项拨款中提出的工作有一个长期目标，即了解 神经系统让我们能够控制运动 解剖学和 生理学将被用来调查有关的基本问题 小脑功能 解剖学研究将利用最近的 引进技术（标记凝集素的运输和演示） 其对于同时跟踪输入是强大且有效的， 神经系统小区域的输出连接。 地区 小脑参与控制特定的肢体运动将被定义 比以往任何时候都要精确 肢体特定部位 猫和猴的大细胞红核和间位核 将通过电生理技术进行识别，并注射 HRP标记麦胚凝集素。 结合解剖学研究， 相同区域的功能特性将通过 在行为猴子中使用慢性单单位记录。 录音将 当受试者执行各种高度训练的运动任务时， 并且神经信号将与特定的运动参数相关。 通过这种方式，了解小脑在正常情况下的作用， 将获得运动。 一些基本的问题比如小脑 是在纠错或初始电机编程中起作用的， 一种“语言”，它是否执行其运动功能将得到回答。 所获得的信息将在研究、诊断和 治疗影响运动的病理状态。 的最新进展 生物技术使研究人员试图模仿神经运动控制 用于修复目的。 了解参与的神经信号 电机控制是指导和评估可行性的前提 各种临床方法。

The work proposed in this grant has the long term goal of understanding the neural systems which allow us to control movement. Both anatomy and physiology will be used to investigate fundamental questions concerning cerebellar functions. The anatomical studies will make use of recently introduced techniques (transport and demonstration of labeled lectins) which are powerful and efficient for simultaneously tracing input and output connections of small areas of the nervous system. Areas of the cerebellum involved in controlling specific limb movements will be defined with more precision than has yet been accomplished. Limb specific portions of the magnocellular red nucleus and interpositus nucleus of cat and monkey will be identified with electrophysiological techniques and injected with HRP labeled wheat germ lectin. In combination with the anatomical studies, the functional properties of the same areas will be determined through the use of chronic single unit recording in behaving monkeys. Recordings will be made while the subjects perform a variety of highly trained motor tasks, and the neural signals will be related to specific parameters of movement. In this way, an understanding of the role the cerebellum plays in normal movements will be gained. Basic questions such as whether the cerebellum is acting in error correction or initital motor programming and with what sort of "language" does it carry out its motor functions will be answered. The information gained will be valuable in the study, diagnosis and treatment of pathological states affecting movement. Recent advances in biotechnology have led researchers to attempt to mimic neural motor control for prosthetic purposes. Understanding the neural signals involved in motor control is a prerequisite for guiding and evaluating the feasibility of various clinical approaches.