FOLLOWUP STUDY OF NEUROLOGICAL RISKS IN AMATEUR BOXERS

参与拳击可能造成的长期脑损伤是 有争议，可能与更广泛的头部受伤问题有关。 在许多方面，业余拳击中发生的伤害，这项运动在很大程度上 不同于职业拳击，类似于发生在 其他运动和事故。脑损伤是否发生在脑部的研究 业余拳击手和对潜伏期的定量评估 由损伤引起的神经行为和其他变化具有潜在的广泛性 这意味着什么。 1988年8月，我们完成了对486名业余拳击手的基线研究。 这项研究的目的是确定选定的变化是否 神经心理学、神经学和神经生理学测量是 与拳击暴露有关。这项研究的独特之处在于 拳击手在任何明显的损伤迹象之前就被识别出来，这是 预期，涉及具有代表性的拳击手样本，并利用 低至未暴露的内部控制组。 1988年8月，我们获得了来自美国国立卫生研究院(ROI)的拨款 NS26450-01)，在该人群中进行第一次随访(FULL)研究。 我们只为一次后续检查申请资金，因为 不确定因素能够成功地遵循这一点 市中心，较低的社会经济地位，年轻的男性人口。到目前为止的随访率 (95%已定位，83%已重新测试)已超过我们的 期望值。数据收集工作将于1990年8月完成。 我们建议在这方面再进行两次跟进检查 同样的人口，在最初的基线研究后四年和六年。 在基线和当前的FU1研究中，神经心理学， 电生理学和神经学测量在4小时内完成 考试。我们还建议延长并最终确定暴露模型 目前正在开发中。这项工作包括获取详细的 拳击手的比赛历史，需要验证的记录副本 主题报告，在陪练条件下测量头部加速度， 并进行了一项研究，比较了关于他们拳击风格的主题报告 使用结构化问卷对他们观察到的拳击风格进行调查。在……里面 到目前为止收集的数据，拳击风格在一个结构化的报告中 采访是对比赛结果的预测。这是对它的提炼 数据可能会提供更有效和更通用的代理 以补充目前正在收集的其他暴露数据。

Possible long term cerebral damage from participation in boxing is controversial and may be relevant to the broader issues of head injuries. In many ways, the injuries that occur in amateur boxing, a sport vastly different from professional boxing, are similar to those that occur in other sports and accidents. A study of whether cerebral damage occurs in amateur boxers and a quantitative assessment of the latency to neurobehavioral and other changes due to damage has potentially broad implications. In August, 1988 we completed a baseline study of 486 amateur boxers. The aim of this study has been to determine if changes in selected neuropsychologic, neurologic, and neurophysiologic measures are associated with exposures from boxing. This study is unique in that boxers are identified before any apparent signs of impairment, it is prospective, involves a representative sample of boxers, and make use of a low to nonexposed internal control group. In August, 1988 we were awarded a grant from the NIH (ROI NS26450-01) to conduct the first followup (FUl) study in this population. We requested funds for only a single followup examination because of the uncertainties being able to successfully following this predominantly inner-city, lower SES, young male population. The followup rate to date (95% located, 83% retested) in this population has exceeded our expectations. Data collection will be completed in August, 1990. We propose to conduct two additional followup examinations in this same population, four and six years after the original baseline study. In both the baseline and current FU1 studies, neuropsychologic, electrophysiologic, and neurologic measures have been made in a 4-hour examination. We also propose to extend and finalize the exposure models currently under development. This work includes obtaining detailed histories of competition from the boxers, copies of records to validate subject reports, measuring head acceleration under sparring conditions, and conducting a study comparing subject reports on their boxing style using a structured questionnaire to their observed style of boxing. In data collected to date, the style of boxing reported in a structured interview is a predictor of the outcome of bouts. A refinement of this data is likely to provide a more valid and generalized surrogate of exposure to complement other exposure data currently being collected.