15TH INTERNATIONAL HERPESVIRUS WORKSHOP

该提案要求提供资金，使科学家，特别是年轻的科学家， 研究人员，参加第十五届国际疱疹病毒研讨会， 乔治敦大学，位于华盛顿，华盛顿特区，1990年8月2日至8日强度 本次研讨会的重要性和意义在于支持和参与， 领先的研究人员，有前途的年轻研究人员和学生， 培训和广泛的国际参与。参与者包括 分子生物学、免疫学、肿瘤形成、发病机理、 潜伏期、流行病学、临床研究和生物医学方法 治疗和预防。许多演讲将涉及 人类疱疹病毒，引起广泛的疾病综合征。这些 包括瘤形成，如鼻咽癌、伯基特淋巴瘤 和B细胞瘤形成，均与EB病毒相关;以及 感染性疾病，如皮肤和眼溃疡（HSV-1）、生殖器溃疡、 病变（HSV-2）、传染性单核细胞增多症（EBV）和水痘， 带状疱疹（VZV）。在新生儿中，先天性CMV感染是导致新生儿感染的主要原因。 智力迟钝和先天缺陷。所有的人类疱疹病毒 持续终生，因此在治疗中造成重大问题 和免疫抑制的管理。癌症患者，器官 移植受者和艾滋病患者特别容易受到 潜伏的HSV、EBV、CMV和VZV的再活化，导致增加的 发病率和死亡率。自身免疫性疾病（类风湿性关节炎）和 神经系统疾病（亚急性脊髓视神经病变）也已被 与疱疹病毒有关动物疱疹病毒具有 对家禽具有重要的经济意义（马立克氏病病毒）， 猪（伪狂犬病病毒）和奶制品（牛鼻气管炎病毒） 马疱疹病毒对马造成重大损失 饲养员此外，与猴疱疹病毒相关的肿瘤 和马立克氏病病毒作为模型系统， 疱疹病毒致癌性的潜在基础。 讲习班的组织者是伦纳德J.罗森塔尔博士和加里R. 皮尔森说， 医学中心 主题包括：基因调控，潜伏期和发病机制，免疫学， 肿瘤，复制，糖蛋白和结构蛋白，酶和 非结构蛋白，艾滋病和疱疹病毒。

This proposal requests funds to enable scientists, especially young investigators, to attend the 15th International Herpesvirus Workshop at Georgetown University in Washington, D.C., August 2-8, 1990. The strength and importance of this workshop rest on support and participation of leading researchers, promising young investigators and students in training, and broad-based international attendance. Participants include specialists in molecular biology, immunology, neoplasia, pathogenesis, latency, epidemiology, clinical investigations, and biomedical approaches to treatment and prevention. Many of the presentations will deal with the human herpesviruses, which cause a wide range of disease syndromes. These include neoplasia, such as nasopharyngeal carcinoma, Burkitt's lymphoma, and B-cell neoplasia, all associated with Epstein-Barr virus; and infectious diseases such as skin and eye ulcerations (HSV-l), genital lesions (HSV-2), infectious mononucleosis (EBV), and chicken pox and shingles (VZV). In neonates congenital CMV infections are a major cause of mental retardation and birth defects. All of the human herpesviruses persist for life and therefore pose significant problems in the treatment and management of the immunologically suppressed. Cancer patients, organ transplant recipients and AIDS patients are particularly susceptible to reactivation of latent HSV, EBV, CMV, and VZV, resulting in increased morbidity and mortality. Autoimmune diseases (rheumatoid arthritis) and neurological diseases (subacute-myelo-optico-Neuropathy) have also been reported to be linked to herpesviruses. Animal herpesviruses have significant economic importance to the poultry (Marek's Disease virus), swine (Pseudorabies virus), and dairy (bovine rhinotracheitis virus) industries and the equine herpesviruses cause significant losses to horse breeders. In addition, neoplasia associated with simian herpesvirus saimiri and Marek's disease virus serve as model systems for studying the underlying basis of herpesvirus oncogenicity. The Workshop organizers are Dr. Leonard J. Rosenthal and Dr. Gary R. Pearson, both at the Department of Microbiology, Georgetown University Medical Center. The topics include: gene regulation, latency and pathogenesis, immunology, neoplasia, replication, glycoproteins and structural proteins, enzymes and nonstructural proteins, and AIDS and herpesviruses.